Epigenetic Effects of Paternal Diet on Offspring: Emphasis on Obesity

Overview

Journal Endocrine

Specialty Endocrinology

Date 2014 Jul 7

PMID 24997644

Citations 24

Authors

Yuriy Slyvka

Yizhu Zhang

Felicia V Nowak

Affiliations

Soon will be listed here.

Abstract

Overnutrition, obesity, and the rise in associated comorbidities are widely recognized as preventable challenges to global health. Behavioral, metabolic, and epigenetic influences that alter the epigenome, when passed on to offspring, can increase their risk of developing an altered metabolic profile. This review is focused on the role of paternal inheritance as demonstrated by clinical, epidemiological, and experimental models. Development of additional experimental models that resemble the specific epigenetic sensitive situations in human studies will be essential to explore paternally induced trans-generational effects that are mediated, primarily, by epigenetic effects. Further elucidation of epigenetic marks will help identify preventive and therapeutic targets, which in combination with healthy lifestyle choices, can diminish the growing tide of obesity, type 2 diabetes, and other related disorders.

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