Advances in Astrocyte-targeted Approaches for Stroke Therapy: an Emerging Role for Mitochondria and MicroRNAS

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2014 Jul 5

PMID 24993363

Citations 16

Authors

Creed M Stary

Rona G Giffard

Affiliations

Soon will be listed here.

Abstract

Astrocytes are critical regulators of neuronal function and an effective target for stroke therapy in animal models. Identifying individual targets with the potential for simultaneous activation of multiple downstream pathways that regulate astrocyte homeostasis may be a necessary element for successful clinical translation. Mitochondria and microRNAs each represent individual targets with multi-modal therapeutic potential. Mitochondria regulate metabolism and apoptosis, while microRNAs have the capacity to bind and inhibit numerous mRNAs. By combining strategies targeted at maintaining astrocyte function during and following cerebral ischemia, a synergistic therapeutic effect may be achieved.

Citing Articles

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