New Answers to Old Questions from Genome-wide Maps of DNA Methylation in Hematopoietic Cells

Overview

Journal Exp Hematol

Specialty Hematology

Date 2014 Jul 5

PMID 24993071

Citations 21

Authors

Mira Jeong

Margaret A Goodell

Affiliations

Soon will be listed here.

Abstract

DNA methylation is a well-studied epigenetic modification essential for efficient cellular differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer, including myeloid malignancies such as acute myeloid leukemia. Recurrent mutations in DNA-modifying enzymes were identified in acute myeloid leukemia and linked to distinct DNA methylation signatures. In addition, discovery of Tet enzymes provided new mechanisms for the reversal of DNA methylation. Advances in base-resolution profiling of DNA methylation have enabled a more comprehensive understanding of the methylome landscape in the genome. This review will summarize and discuss the key questions in the function of DNA methylation in the hematopoietic system, including where and how DNA methylation regulates diverse biological processes in the genome as elucidated by recent studies.

Citing Articles

Exploration of the prognostic value of methylation regulators related to m5C in papillary thyroid carcinoma.

Nie F, Jiang J, Ning J Medicine (Baltimore). 2024; 103(25):e38623.

PMID: 38905403 PMC: 11191899. DOI: 10.1097/MD.0000000000038623.

The use of SP/Neurokinin-1 as a Therapeutic Target in Colon and Rectal Cancer.

Martin-Garcia D, Tellez T, Redondo M, Garcia-Aranda M Curr Med Chem. 2023; 31(39):6487-6509.

PMID: 37861026 DOI: 10.2174/0109298673261625230924114406.

Scurvy: A treatable forgotten fatal differential diagnosis and potential etiology of leukemia and aplastic anemia in pediatric population.

Mashauri H Health Sci Rep. 2023; 6(10):e1611.

PMID: 37808934 PMC: 10552072. DOI: 10.1002/hsr2.1611.

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.

Desaulniers D, Vasseur P, Jacobs A, Aguila M, Ertych N, Jacobs M Int J Mol Sci. 2021; 22(20).

PMID: 34681626 PMC: 8535778. DOI: 10.3390/ijms222010969.

Functional Interplay between Methyltransferases and Inflammasomes in Inflammatory Responses and Diseases.

Yi Y Int J Mol Sci. 2021; 22(14).

PMID: 34299198 PMC: 8306412. DOI: 10.3390/ijms22147580.

References

Maunakea A, Chepelev I, Cui K, Zhao K . Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013; 23(11):1256-69. PMC: 3817542. DOI: 10.1038/cr.2013.110. View

Ziller M, Gu H, Muller F, Donaghey J, Tsai L, Kohlbacher O . Charting a dynamic DNA methylation landscape of the human genome. Nature. 2013; 500(7463):477-81. PMC: 3821869. DOI: 10.1038/nature12433. View

Toyota M, Issa J . Epigenetic changes in solid and hematopoietic tumors. Semin Oncol. 2005; 32(5):521-30. DOI: 10.1053/j.seminoncol.2005.07.003. View

Lippman Z, Gendrel A, Black M, Vaughn M, Dedhia N, McCombie W . Role of transposable elements in heterochromatin and epigenetic control. Nature. 2004; 430(6998):471-6. DOI: 10.1038/nature02651. View

Shearstone J, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M . Global DNA demethylation during mouse erythropoiesis in vivo. Science. 2011; 334(6057):799-802. PMC: 3230325. DOI: 10.1126/science.1207306. View

Fenaux P, Mufti G, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A . Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009; 10(3):223-32. PMC: 4086808. DOI: 10.1016/S1470-2045(09)70003-8. View

Russler-Germain D, Spencer D, Young M, Lamprecht T, Miller C, Fulton R . The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014; 25(4):442-54. PMC: 4018976. DOI: 10.1016/j.ccr.2014.02.010. View

Kriaucionis S, Heintz N . The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science. 2009; 324(5929):929-30. PMC: 3263819. DOI: 10.1126/science.1169786. View

Riggs A . X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet. 1975; 14(1):9-25. DOI: 10.1159/000130315. View

10.

Heyn H, Vidal E, Sayols S, Sanchez-Mut J, Moran S, Medina I . Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient. Epigenetics. 2012; 7(6):542-50. PMC: 3398983. DOI: 10.4161/epi.20523. View

11.

Pastor W, Pape U, Huang Y, Henderson H, Lister R, Ko M . Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011; 473(7347):394-7. PMC: 3124347. DOI: 10.1038/nature10102. View

12.

Yu M, Hon G, Szulwach K, Song C, Jin P, Ren B . Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc. 2012; 7(12):2159-70. PMC: 3641661. DOI: 10.1038/nprot.2012.137. View

13.

Straussman R, Nejman D, Roberts D, Steinfeld I, Blum B, Benvenisty N . Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol. 2009; 16(5):564-71. DOI: 10.1038/nsmb.1594. View

14.

Broske A, Vockentanz L, Kharazi S, Huska M, Mancini E, Scheller M . DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet. 2009; 41(11):1207-15. DOI: 10.1038/ng.463. View

15.

Szulwach K, Li X, Li Y, Song C, Han J, Kim S . Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet. 2011; 7(6):e1002154. PMC: 3121778. DOI: 10.1371/journal.pgen.1002154. View

16.

Li E, Bestor T, Jaenisch R . Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992; 69(6):915-26. DOI: 10.1016/0092-8674(92)90611-f. View

17.

Tsai H, Li H, Van Neste L, Cai Y, Robert C, Rassool F . Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 2012; 21(3):430-46. PMC: 3312044. DOI: 10.1016/j.ccr.2011.12.029. View

18.

Kim S, Zhao H, Hardikar S, Singh A, Goodell M, Chen T . A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013; 122(25):4086-9. PMC: 3952368. DOI: 10.1182/blood-2013-02-483487. View

19.

Wu H, DAlessio A, Ito S, Xia K, Wang Z, Cui K . Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011; 473(7347):389-93. PMC: 3539771. DOI: 10.1038/nature09934. View

20.

Challen G, Sun D, Jeong M, Luo M, Jelinek J, Berg J . Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011; 44(1):23-31. PMC: 3637952. DOI: 10.1038/ng.1009. View