Advances in the Management of Squamous Cell Carcinoma of the Head and Neck

Overview

Journal F1000Prime Rep

Specialty Biomedical Engineering

Date 2014 Jul 4

PMID 24991421

Citations 48

Authors

Jean-Pascal Machiels

Maarten Lambrecht

Francois-Xavier Hanin

Thierry Duprez

Vincent Gregoire

Sandra Schmitz

Marc Hamoir

Affiliations

Soon will be listed here.

Abstract

Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. The main risk factors for cancers of the oral cavity, larynx, oropharynx, and hypopharynx are alcohol and tobacco use. In addition, the human papillomavirus (HPV) is an established cause of oropharyngeal cancer. An experienced multidisciplinary team is necessary for adequate management and optimal outcome. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy, but despite this aggressive multimodal treatment, 40% to 60% of the patients will relapse. In this report, we will discuss recent advances in the management of SCCHN, including new developments in molecular biology, imaging, and treatment.

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