Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer

Overview

Journal Pathol Oncol Res

Specialty Oncology

Date 2014 Jul 4

PMID 24990775

Citations 9

Authors

Rafael Ascencio-Cedillo

Edgar Ivan Lopez-Pulido

Jose Francisco Munoz-Valle

Nicolas Villegas-Sepulveda

Susana Del Toro-Arreola

Ciro Estrada-Chavez

Adrian Daneri-Navarro

Ramon Franco-Topete

Delia Perez-Montiel

Alejandro Garcia-Carranca

Ana Laura Pereira-Suarez

Affiliations

Soon will be listed here.

Abstract

Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.

Citing Articles

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women.

Hernandez-Silva C, Ramirez de Arellano A, Pereira-Suarez A, Ramirez-Lopez I Viruses. 2024; 16(3).

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4SC-202 exerts an anti-tumor effect in cervical cancer by targeting PRLR signaling pathway.

Zhang H, Li M, Sun H, Yang W, Ye M, Li H J Mol Histol. 2022; 53(6):891-902.

PMID: 36272045 DOI: 10.1007/s10735-022-10105-6.

Differential modulation of natural killer cell cytotoxicity by 17β-estradiol and prolactin through the NKG2D/NKG2DL axis in cervical cancer cells.

Godoy-Pacheco A, Garcia-Chagollan M, Ramirez-de-Arellano A, Hernandez-Silva C, Villegas-Pineda J, Ramirez-Lopez I Oncol Lett. 2022; 24(2):288.

PMID: 35814823 PMC: 9260731. DOI: 10.3892/ol.2022.13408.

The Relevant Participation of Prolactin in the Genesis and Progression of Gynecological Cancers.

Ramirez-de-Arellano A, Villegas-Pineda J, Hernandez-Silva C, Pereira-Suarez A Front Endocrinol (Lausanne). 2021; 12:747810.

PMID: 34745013 PMC: 8566755. DOI: 10.3389/fendo.2021.747810.

The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain.

Costa-Brito A, Quintela T, Goncalves I, Duarte A, Costa A, Arosa F Mol Neurobiol. 2021; 58(4):1846-1858.

PMID: 33409838 DOI: 10.1007/s12035-020-02267-9.

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