FGF5 is a Crucial Regulator of Hair Length in Humans

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2014 Jul 4

PMID 24989505

Citations 72

Authors

Claire A Higgins

Lynn Petukhova

Sivan Harel

Yuan Y Ho

Esther Drill

Lawrence Shapiro

Muhammad Wajid

Angela M Christiano

Affiliations

Soon will be listed here.

Abstract

Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or extreme eyelash growth. Using a combination of whole exome sequencing and homozygosity mapping, we identified distinct pathogenic mutations within fibroblast growth factor 5 (FGF5) that underlie the disorder. Subsequent sequencing of this gene in several additional trichomegaly families identified an additional mutation in FGF5. We further demonstrated that hair fibers from forearms of these patients were significantly longer than hairs from control individuals, with an increased proportion in the growth phase, anagen. Using hair follicle organ cultures, we show that FGF5 induces regression of the human hair follicle. We have identified FGF5 as a crucial regulator of hair growth in humans for the first time, to our knowledge, and uncovered a therapeutic target to selectively regulate eyelash growth.

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