Epithelial-myoepithelial Carcinoma of the Parotid Gland: Clinicopathological Aspect, Diagnosis and Surgical Consideration

Overview

Journal Ann Maxillofac Surg

Date 2014 Jul 3

PMID 24987609

Citations 12

Authors

Massimo Politi

Massimo Robiony

Claudio Avellini

Maria Orsaria

Affiliations

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Abstract

The present paper describes the clinical and pathological features of epithelial-myoepithelial carcinoma (EMC) of the parotid gland. This rare tumor represents <1% of all salivary gland tumors and arises most commonly in the parotid gland, but it has also been described in the submandibular gland, minor salivary glands and palate. EMC is considered to be a low-grade malignant tumor that may commonly recur locally after resection in 23-50% of cases. The complex and varied morphological expression of this neoplasm has attracted numerous investigators, who have presented valuable but often contradictory data. After an in-depth analysis of the clinicopathological aspects of EMC, we speculate that adequate resection with negative soft-tissue margins is the minimum recommended and necessary therapy.

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References

Darvishian F, Lin O . Myoepithelial cell-rich neoplasms: cytologic features of benign and malignant lesions. Cancer. 2004; 102(6):355-61. DOI: 10.1002/cncr.20642. View

Corio R, Sciubba J, Brannon R, BATSAKIS J . Epithelial-myoepithelial carcinoma of intercalated duct origin. A clinicopathologic and ultrastructural assessment of sixteen cases. Oral Surg Oral Med Oral Pathol. 1982; 53(3):280-7. DOI: 10.1016/0030-4220(82)90304-8. View

Goldman R, KLEIN H . Glycogen-rich adenoma of the parotid gland. An uncommon benign clear-cell tumor resembling certain clear-cell carcinomas of salivary origin. Cancer. 1972; 30(3):749-54. DOI: 10.1002/1097-0142(197209)30:3<749::aid-cncr2820300324>3.0.co;2-9. View

Mohamed A, Cherrick H . Glycogen-rich adenocarcinoma of minor salivary glands. A light and electron microscopic study. Cancer. 1975; 36(3):1057-66. DOI: 10.1002/1097-0142(197509)36:3<1057::aid-cncr2820360332>3.0.co;2-p. View

Yamazaki H, Ota Y, Aoki T, Kaneko A . Lung metastases of epithelial-myoepithelial carcinoma of the parotid gland successfully treated with chemotherapy: a case report. J Oral Maxillofac Surg. 2012; 71(1):220-6. DOI: 10.1016/j.joms.2012.03.031. View

Seifert G . Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?. Virchows Arch. 1998; 433(3):285-8. DOI: 10.1007/s004280050249. View

Silvers A, Som P, Brandwein M . Epithelial-myoepithelial carcinoma of the parotid gland. AJNR Am J Neuroradiol. 1996; 17(3):560-2. PMC: 8337975. View

Morinaga S, Hashimoto S, Tezuka F . Epithelial-myoepithelial carcinoma of the parotid gland in a child. Acta Pathol Jpn. 1992; 42(5):358-63. DOI: 10.1111/j.1440-1827.1992.tb02886.x. View

Saksela E, Tarkkanen J, WARTIOVAARA J . Parotid clear-cell adenoma of possible myoepithelial origin. Cancer. 1972; 30(3):742-8. DOI: 10.1002/1097-0142(197209)30:3<742::aid-cncr2820300323>3.0.co;2-x. View

10.

Hamper K, Brugmann M, Koppermann R, Caselitz J, Arps H, Askensten U . Epithelial-myoepithelial duct carcinoma of salivary glands: a follow-up and cytophotometric study of 21 cases. J Oral Pathol Med. 1989; 18(5):299-304. DOI: 10.1111/j.1600-0714.1989.tb00401.x. View

11.

Luna M, Ordonez N, Mackay B, BATSAKIS J, Guillamondegui O . Salivary epithelial-myoepithelial carcinomas of intercalated ducts: a clinical, electron microscopic, and immunocytochemical study. Oral Surg Oral Med Oral Pathol. 1985; 59(5):482-90. DOI: 10.1016/0030-4220(85)90089-1. View

12.

Friedrich R, Donath K . Epithelial-myoepithelial carcinoma of the parotid gland with multiple distant metastases: a case report. J Oral Maxillofac Surg. 2000; 58(6):690-4. DOI: 10.1016/s0278-2391(00)90171-x. View

13.

Zbaren P, Vander Poorten V, Witt R, Woolgar J, Shaha A, Triantafyllou A . Pleomorphic adenoma of the parotid: formal parotidectomy or limited surgery?. Am J Surg. 2012; 205(1):109-18. DOI: 10.1016/j.amjsurg.2012.05.026. View

14.

Tralongo V, Daniele E . Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. Anticancer Res. 1998; 18(1B):603-8. View

15.

Seethala R, Barnes E, Hunt J . Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007; 31(1):44-57. DOI: 10.1097/01.pas.0000213314.74423.d8. View

16.

Fonseca I, Soares J . Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases. Virchows Arch A Pathol Anat Histopathol. 1993; 422(5):389-96. DOI: 10.1007/BF01605458. View

17.

Palmer R . Epithelial-myoepithelial carcinoma: an immunocytochemical study. Oral Surg Oral Med Oral Pathol. 1985; 59(5):511-5. DOI: 10.1016/0030-4220(85)90093-3. View

18.

Donath K, Seifert G, Schmitz R . [Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts]. Virchows Arch A Pathol Pathol Anat. 1972; 356(1):16-31. View

19.

Chen K . Clear cell carcinoma of the salivary gland. Hum Pathol. 1983; 14(1):91-3. DOI: 10.1016/s0046-8177(83)80053-7. View

20.

Baker A, Ohanessian S, Adil E, Crist H, Goldenberg D, Mani H . Dedifferentiated epithelial-myoepithelial carcinoma: analysis of a rare entity based on a case report and literature review. Int J Surg Pathol. 2012; 21(5):514-9. DOI: 10.1177/1066896912468153. View