The Kinetochore

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2014 Jul 3

PMID 24984773

Citations 184

Authors

Iain M Cheeseman

Affiliations

Soon will be listed here.

Abstract

A critical requirement for mitosis is the distribution of genetic material to the two daughter cells. The central player in this process is the macromolecular kinetochore structure, which binds to both chromosomal DNA and spindle microtubule polymers to direct chromosome alignment and segregation. This review will discuss the key kinetochore activities required for mitotic chromosome segregation, including the recognition of a specific site on each chromosome, kinetochore assembly and the formation of kinetochore-microtubule connections, the generation of force to drive chromosome segregation, and the regulation of kinetochore function to ensure that chromosome segregation occurs with high fidelity.

Citing Articles

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The KNL-1/Knl1 outer kinetochore protein caught regulating F-actin.

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Binding site maturation modulated by molecular density underlies Ndc80 binding to kinetochore receptor CENP-T.

Tarasovetc E, Sissoko G, Maiorov A, Mukhina A, Ataullakhanov F, Cheeseman I Proc Natl Acad Sci U S A. 2024; 121(52):e2401344121.

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