[Update of the S3 Guidelines for Pancreatic Cancer. What is New for Pathologists?]

Overview

Journal Pathologe

Specialty Pathology

Date 2014 Jul 2

PMID 24981895

Citations 2

Authors

J Munding

J Luttges

I Esposito

A Tannapfel

Affiliations

Soon will be listed here.

Abstract

The S3 guidelines for pancreatic cancer were revised in 2013. Besides the oncological and palliative therapy modalities and surgical therapy, the guidelines for pathologists in topic 3 were updated. The modifications essentially concern the histopathological assessment of surgical specimens and in particular the circumferential resection margin and the R classification. In addition, the current recommendations were amended by recommendations concerning the pathohistological records, which should include the lymph node ratio in the future.

Citing Articles

[Pathology of the R1 classification in visceral cancer surgery].

Pollheimer M, Langner C Chirurg. 2017; 88(9):731-739.

PMID: 28593347 DOI: 10.1007/s00104-017-0448-6.

[What is new in the pathology of pancreatic neuroendocrine tumors?].

Komminoth P, Perren A Pathologe. 2015; 36(3):220-8.

PMID: 25941099 DOI: 10.1007/s00292-015-0023-1.

References

Seufferlein T, Adler G . [The S3 guideline exocrine pancreatic cancer]. Med Klin (Munich). 2009; 104(11):869-74. DOI: 10.1007/s00063-009-1183-7. View

Wittekind C, Compton C, Quirke P, Nagtegaal I, Merkel S, Hermanek P . A uniform residual tumor (R) classification: integration of the R classification and the circumferential margin status. Cancer. 2009; 115(15):3483-8. DOI: 10.1002/cncr.24320. View

Raut C, Tseng J, Sun C, Wang H, Wolff R, Crane C . Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg. 2007; 246(1):52-60. PMC: 1899216. DOI: 10.1097/01.sla.0000259391.84304.2b. View

Seelig M, Janot M, Chromik A, Herzog T, Belyaev O, Weyhe D . Redo-surgery following curative resection of pancreatic carcinoma: the difference between true and suspected recurrence. Dig Surg. 2009; 26(3):222-8. DOI: 10.1159/000219332. View

Chang D, Johns A, Merrett N, Gill A, Colvin E, Scarlett C . Margin clearance and outcome in resected pancreatic cancer. J Clin Oncol. 2009; 27(17):2855-62. DOI: 10.1200/JCO.2008.20.5104. View

Adler G, Seufferlein T, Bischoff S, Brambs H, Feuerbach S, Grabenbauer G . [S3-Guidelines "Exocrine pancreatic cancer" 2007]. Z Gastroenterol. 2007; 45(6):487-523. DOI: 10.1055/s-2007-963224. View

Munding J, Uhl W, Tannapfel A . [R classification and pancreatic ductal adenocarcinoma--R 0 is R 0]. Z Gastroenterol. 2011; 49(10):1423-7. DOI: 10.1055/s-0031-1281750. View

Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H . Most pancreatic cancer resections are R1 resections. Ann Surg Oncol. 2008; 15(6):1651-60. DOI: 10.1245/s10434-008-9839-8. View

Jones S, Zhang X, Parsons D, Cheng-Ho Lin J, Leary R, Angenendt P . Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008; 321(5897):1801-6. PMC: 2848990. DOI: 10.1126/science.1164368. View

10.

Tannapfel A, Denk H, Dienes H, Langner C, Schirmacher P, Trauner M . [Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease. Grade 2 consensus-based guidelines]. Pathologe. 2010; 31(3):225-37. DOI: 10.1007/s00292-010-1274-5. View

11.

Campbell F, Smith R, Whelan P, Sutton R, Raraty M, Neoptolemos J . Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin. Histopathology. 2009; 55(3):277-83. DOI: 10.1111/j.1365-2559.2009.03376.x. View

12.

Verbeke C . Resection margins and R1 rates in pancreatic cancer--are we there yet?. Histopathology. 2007; 52(7):787-96. DOI: 10.1111/j.1365-2559.2007.02935.x. View

13.

Verbeke C, Knapp J, Gladhaug I . Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment. Histopathology. 2011; 59(6):1111-21. DOI: 10.1111/j.1365-2559.2011.04056.x. View

14.

Jamieson N, Foulis A, Oien K, Going J, Glen P, Dickson E . Positive mobilization margins alone do not influence survival following pancreatico-duodenectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2010; 251(6):1003-10. DOI: 10.1097/SLA.0b013e3181d77369. View

15.

Menon K, Gomez D, Smith A, Anthoney A, Verbeke C . Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds Pathology Protocol (LEEPP). HPB (Oxford). 2009; 11(1):18-24. PMC: 2697870. DOI: 10.1111/j.1477-2574.2008.00013.x. View

16.

Fietkau R, Heinemann V, Oettle H, Knoefel W, Tannapfel A . [New data on pancreatic cancer]. Onkologie. 2010; 33 Suppl 4:31-5. DOI: 10.1159/000308453. View

17.

Chatterjee D, Katz M, Rashid A, Varadhachary G, Wolff R, Wang H . Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome. Cancer. 2011; 118(12):3182-90. PMC: 3269538. DOI: 10.1002/cncr.26651. View

18.

Costello E, Greenhalf W, Neoptolemos J . New biomarkers and targets in pancreatic cancer and their application to treatment. Nat Rev Gastroenterol Hepatol. 2012; 9(8):435-44. DOI: 10.1038/nrgastro.2012.119. View

19.

Reid M, Bagci P, Adsay N . Histopathologic assessment of pancreatic cancer: does one size fit all?. J Surg Oncol. 2012; 107(1):67-77. DOI: 10.1002/jso.23194. View

20.

Vincent A, Herman J, Schulick R, Hruban R, Goggins M . Pancreatic cancer. Lancet. 2011; 378(9791):607-20. PMC: 3062508. DOI: 10.1016/S0140-6736(10)62307-0. View