Preclinical in Vitro Screening Assays for Drug-like Properties

Overview

Journal Drug Discov Today Technol

Publisher Elsevier

Date 2014 Jul 2

PMID 24981846

Citations 13

Authors

Albert P Li

Affiliations

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Abstract

Besides pharmacological effects, ADMET drug properties, namely, absorption, disposition, metabolism, elimination and toxicity, are important drug properties critical for clinical success. In vitro human-based experimental system used in combination with in vivo animal systems, using animal species relevant to humans, represent the best approach to assess these important drug-like properties before clinical trials. Selection of drug candidates with the best ADMET properties should enhance the probability of clinical success.:

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