Tantalum Oxide Nanoparticles for the Imaging of Articular Cartilage Using X-ray Computed Tomography: Visualization of Ex Vivo/in Vivo Murine Tibia and Ex Vivo Human Index Finger Cartilage

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2014 Jul 2

PMID 24981730

Citations 25

Authors

Jonathan D Freedman

Hrvoje Lusic

Brian D Snyder

Mark W Grinstaff

Affiliations

Soon will be listed here.

Abstract

The synthesis and characterization of tantalum oxide (Ta2O5) nanoparticles (NPs) as new X-ray contrast media for microcomputed tomography (μCT) imaging of articular cartilage are reported. NPs, approximately 5-10 nm in size, and possessing distinct surface charges, were synthesized using phosphonate (neutral), ammonium (cationic), and carboxylate (anionic) ligands as end functional groups. Assessment of a cartilage defect in a human cadaver distal metacarpophalangeal (MCP) joint with the ammonium nanoparticles showed good visualization of damage and preferential uptake in areas surrounding the defect. Finally, an optimized nontoxic cationic NP contrast agent was evaluated in an in vivo murine model and the cartilage was imaged. These nanoparticles represent a new type of contrast agent for imaging articular cartilage, and the results demonstrate the importance of surface charge in the design of nanoparticulate agents for targeting the surface or interior zones of articular cartilage.

Citing Articles

Advancements in tantalum based nanoparticles for integrated imaging and photothermal therapy in cancer management.

Ifijen I, Christopher A, Lekan O, Aworinde O, Faderin E, Obembe O RSC Adv. 2024; 14(46):33681-33740.

PMID: 39450067 PMC: 11498270. DOI: 10.1039/d4ra05732e.

Molecular imaging nanoprobes and their applications in atherosclerosis diagnosis.

Kou H, Yang H Theranostics. 2024; 14(12):4747-4772.

PMID: 39239513 PMC: 11373619. DOI: 10.7150/thno.96037.

Iodinated gadolinium-gold nanomaterial as a multimodal contrast agent for cartilage tissue imaging.

Lu C, Lian W, Wu R, Lin Y, Su C, Chen C APL Bioeng. 2024; 8(3):036110.

PMID: 39165611 PMC: 11335359. DOI: 10.1063/5.0215273.

Functional Nanomaterials for the Treatment of Osteoarthritis.

Yi X, Leng P, Wang S, Liu L, Xie B Int J Nanomedicine. 2024; 19:6731-6756.

PMID: 38979531 PMC: 11230134. DOI: 10.2147/IJN.S465243.

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review.

Liang W, Zhou C, Bai J, Zhang H, Long H, Jiang B Front Bioeng Biotechnol. 2024; 12:1342340.

PMID: 38567086 PMC: 10986186. DOI: 10.3389/fbioe.2024.1342340.

References

Parkesh R, Gowin W, Lee T, Gunnlaugsson T . Synthesis and evaluation of potential CT (computer tomography) contrast agents for bone structure and microdamage analysis. Org Biomol Chem. 2006; 4(19):3611-7. DOI: 10.1039/b606976b. View

Joshi N, Bansal P, Stewart R, Snyder B, Grinstaff M . Effect of contrast agent charge on visualization of articular cartilage using computed tomography: exploiting electrostatic interactions for improved sensitivity. J Am Chem Soc. 2009; 131(37):13234-5. DOI: 10.1021/ja9053306. View

Botter S, van Osch G, Clockaerts S, Waarsing J, Weinans H, van Leeuwen J . Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study. Arthritis Rheum. 2011; 63(9):2690-9. DOI: 10.1002/art.30307. View

Stewart R, Bansal P, Entezari V, Lusic H, Nazarian R, Snyder B . Contrast-enhanced CT with a high-affinity cationic contrast agent for imaging ex vivo bovine, intact ex vivo rabbit, and in vivo rabbit cartilage. Radiology. 2012; 266(1):141-50. PMC: 3528972. DOI: 10.1148/radiol.12112246. View

van Tiel J, Siebelt M, Waarsing J, Piscaer T, van Straten M, Booij R . CT arthrography of the human knee to measure cartilage quality with low radiation dose. Osteoarthritis Cartilage. 2012; 20(7):678-85. DOI: 10.1016/j.joca.2012.03.007. View

Bonitatibus Jr P, Torres A, Kandapallil B, Lee B, Goddard G, Colborn R . Preclinical assessment of a zwitterionic tantalum oxide nanoparticle X-ray contrast agent. ACS Nano. 2012; 6(8):6650-8. DOI: 10.1021/nn300928g. View

Bansal P, Stewart R, Entezari V, Snyder B, Grinstaff M . Contrast agent electrostatic attraction rather than repulsion to glycosaminoglycans affords a greater contrast uptake ratio and improved quantitative CT imaging in cartilage. Osteoarthritis Cartilage. 2011; 19(8):970-6. DOI: 10.1016/j.joca.2011.04.004. View

Somers R, Bawendi M, Nocera D . CdSe nanocrystal based chem-/bio- sensors. Chem Soc Rev. 2007; 36(4):579-91. DOI: 10.1039/b517613c. View

Byun S, Tortorella M, Malfait A, Fok K, Frank E, Grodzinsky A . Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Arch Biochem Biophys. 2010; 499(1-2):32-9. PMC: 2885539. DOI: 10.1016/j.abb.2010.04.019. View

10.

Felson D, Lawrence R, Dieppe P, Hirsch R, Helmick C, Jordan J . Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000; 133(8):635-46. DOI: 10.7326/0003-4819-133-8-200010170-00016. View

11.

Yin M, Shen J, Pflugfelder G, Mullen K . A fluorescent core-shell dendritic macromolecule specifically stains the extracellular matrix. J Am Chem Soc. 2008; 130(25):7806-7. DOI: 10.1021/ja8022362. View

12.

de Hooge A, van de Loo F, Bennink M, Arntz O, de Hooge P, van den Berg W . Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage. 2005; 13(1):66-73. DOI: 10.1016/j.joca.2004.09.011. View

13.

Bansal P, Joshi N, Entezari V, Grinstaff M, Snyder B . Contrast enhanced computed tomography can predict the glycosaminoglycan content and biomechanical properties of articular cartilage. Osteoarthritis Cartilage. 2009; 18(2):184-91. DOI: 10.1016/j.joca.2009.09.003. View

14.

Soenen S, de Cuyper M . Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes. Contrast Media Mol Imaging. 2009; 4(5):207-19. DOI: 10.1002/cmmi.282. View

15.

Bajpayee A, Wong C, Bawendi M, Frank E, Grodzinsky A . Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials. 2013; 35(1):538-49. PMC: 3863604. DOI: 10.1016/j.biomaterials.2013.09.091. View

16.

Bhattacharjee S, Rietjens I, Singh M, Atkins T, Purkait T, Xu Z . Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges. Nanoscale. 2013; 5(11):4870-83. PMC: 3667208. DOI: 10.1039/c3nr34266b. View

17.

Rabin O, Perez J, Grimm J, Wojtkiewicz G, Weissleder R . An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater. 2006; 5(2):118-22. DOI: 10.1038/nmat1571. View

18.

Lee N, Hyeon T . Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents. Chem Soc Rev. 2011; 41(7):2575-89. DOI: 10.1039/c1cs15248c. View

19.

Oh M, Lee N, Kim H, Park S, Piao Y, Lee J . Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. J Am Chem Soc. 2011; 133(14):5508-15. DOI: 10.1021/ja200120k. View

20.

Yoo H, Hong S, Choi J, Lee I, Kim S, Choi J . Contrast-enhanced CT of articular cartilage: experimental study for quantification of glycosaminoglycan content in articular cartilage. Radiology. 2011; 261(3):805-12. DOI: 10.1148/radiol.11102495. View