Isolation and Distribution of a Drosophila Protein Preferentially Associated with Active Regions of the Genome

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 1989 Mar 1

PMID 2498046

Authors

B Fleischmann

R Filipski

G Fleischmann

Affiliations

Soon will be listed here.

Abstract

A non-histone chromosomal protein of Mr = 75,000 was isolated from Drosophila embryos. The distribution pattern of this protein was determined by indirect immunofluorescence on salivary gland chromosomes of Drosophila melanogaster third instar larvae and compared with the distribution pattern of RNA polymerase II. Despite its preferential association with transcriptionally active regions of the chromosomes there was in many cases an almost inverse correlation with the RNA polymerase II content of a given locus. We postulate a function of the Mr = 75,000 protein in posttranscriptional regulation of gene expression by storing the newly synthesized RNA.

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