Fusobacterium and Enterobacteriaceae: Important Players for CRC?

Overview

Journal Immunol Lett

Specialty Allergy & Immunology

Date 2014 Jun 28

PMID 24972311

Citations 66

Authors

Emma Allen-Vercoe

Christian Jobin

Affiliations

Soon will be listed here.

Abstract

The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. Not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). In this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and CRC. We will discuss the biological events implicated in the development of microbial dysbiosis and the emergence of CRC-associated microorganisms, focusing on Escherichia coli and Fusobacterium nucleatum. Finally, the mechanisms by which E. coli and F. nucleatum exert potentially carcinogenic effects on the host will be reviewed.

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