CXC and CC Chemokines As Angiogenic Modulators in Nonhaematological Tumors

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Jun 28

PMID 24971349

Citations 34

Authors

Matteo Santoni

Sergio Bracarda

Massimo Nabissi

Francesco Massari

Alessandro Conti

Emilio Bria

Giampaolo Tortora

Giorgio Santoni

Stefano Cascinu

Affiliations

Soon will be listed here.

Abstract

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

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