Ovary Cells Apoptosis in Opium-addicted Diabetic and Non-diabetic Rats

Overview

Journal Int J High Risk Behav Addict

Publisher Brieflands

Specialty Psychology

Date 2014 Jun 28

PMID 24971264

Citations 2

Authors

Gholamreza Asadikaram

Majid Asiabanha

Majid Sirati Sabet

Affiliations

Soon will be listed here.

Abstract

Background: Apoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. It has been indicated that some opium derivatives develop cell apoptosis.

Objectives: The aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic Wistar rats.

Materials And Methods: This experimental study was done on control, control-addicted, diabetic and diabetic-addicted rats. DNA fragmentation as a biomarker of apoptosis was determined by the TUNEL assay.

Results: The blood glucose concentration in diabetic-addicted and diabetic rats was increased when compared to control (P < 0.001). There was no significant difference between weights of control, control-addicted (non-diabetic) and diabetic-addicted groups during this study. The results of this study indicated that apoptosis in addicted and diabetic-addicted ovary cells was significantly higher than in diabetic group, and also apoptosis in addicted group was significantly more than the control rats. In addition, we found that ovary cells apoptosis of diabetic rats were significantly less than in control group.

Conclusions: Overall, these findings suggest that opium-addiction could play an important role in ovary cell apoptosis and could be very harmful for the reproductive system. Also, ovary cells of non-diabetic rats are more susceptible to opium-induced apoptosis than those of diabetic.

Citing Articles

Intergenerational Hyperglycemia Impairs Mitochondrial Function and Follicular Development and Causes Oxidative Stress in Rat Ovaries Independent of the Consumption of a High-Fat Diet.

Paula V, Sinzato Y, Gallego F, Lopes Cruz L, de Aquino A, Scarano W Nutrients. 2023; 15(20).

PMID: 37892483 PMC: 10609718. DOI: 10.3390/nu15204407.

Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats.

Asadikaram G, Vakili S, Akbari H, Kheirmand-Parizi M, Sadeghi E, Asiabanha M Addict Health. 2019; 10(2):123-130.

PMID: 31069036 PMC: 6494983. DOI: 10.22122/ahj.v10i2.531.

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