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Using Tramadol to Measure CYP2D6 Metabolism in Critically Ill Adults

Overview
Journal Intensive Care Med
Specialty Critical Care
Date 2014 Jun 28
PMID 24968714
Citations 2
Authors
Katie Lane
John J Dixon
Denise McKeown
Atholl Johnston
Ron H N van Schaik
Marianne van Fessem
Iain A M MacPhee
Barbara J Philips
Affiliations
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References
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Frank D, Jaehde U, Fuhr U . Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. Eur J Clin Pharmacol. 2007; 63(4):321-33. DOI: 10.1007/s00228-006-0250-8. View
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Kirwan C, Lee T, Holt D, Grounds R, MacPhee I, Philips B . Using midazolam to monitor changes in hepatic drug metabolism in critically ill patients. Intensive Care Med. 2009; 35(7):1271-5. DOI: 10.1007/s00134-009-1430-7. View
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Lin Y, Lockwood G, Graham M, Brian W, Loi C, Dobrinska M . In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. Pharmacogenetics. 2001; 11(9):781-91. DOI: 10.1097/00008571-200112000-00006. View
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Kirwan C, MacPhee I, Lee T, Holt D, Philips B . Acute kidney injury reduces the hepatic metabolism of midazolam in critically ill patients. Intensive Care Med. 2011; 38(1):76-84. DOI: 10.1007/s00134-011-2360-8. View