Transdifferentiation Between Bone and Fat on Bone Metabolism

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2014 Jun 27

PMID 24966894

Citations 11

Authors

Bo Gao

Liu Yang

Zhuo-Jing Luo

Affiliations

Soon will be listed here.

Abstract

The transdifferentiation of bone and fat is a new insight in studying the increasingly bone marrow fat in the process of osteoporosis of elderly or menopause crowd which is increasing in prevalence. The loss of bone mass in osteoporosis is multifactorially determined and includes genetic, hormonal and environmental determinants. Although it has long been considered whether the transdifferentiation process does exist in vivo and whether it could be find in the same individual, interaction between skeleton and adipose tissue has been proved pre-clinically and clinically by increasing evidence. Here we focus on the current understanding of the transdifferentiation between bone and fat, the molecular interactions and future clinical implications of recent studies linking the transdifferentiation to bone metabolism diseases. Furthermore, a set of recommendations of bone and fat transdifferentiation on bone metabolism are also presented to facilitate evaluation of this magic process.

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