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Clinically Relevant Interaction Between Warfarin and Scuppernongs, a Quercetin Containing Muscadine Grape: Continued Questions Surrounding Flavonoid-induced Warfarin Interactions

Overview
Journal BMJ Case Rep
Specialty General Medicine
Date 2014 Jun 27
PMID 24966255
Citations 5
Authors
Christopher J Woodward
Zachariah M Deyo
Katrina E Donahue
Allison M Deal
Emily M Hawes
Affiliations
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Abstract

We present a case of clinically relevant and probable interaction between warfarin and scuppernongs in a 73-year-old woman where ingestion of scuppernongs, a variety of quercetin-containing muscadine grapes, over a period of 2 months was associated with elevations in the International Normalised Ratio to supratherapeutic levels. While muscadine grapes and specifically scuppernongs are found primarily in Southeastern USA, the flavonoid in questionand quercetin is found worldwide as a dietary supplement.

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References
1.
Hapner C, Deuster P, Chen Y . Inhibition of oxidative hemolysis by quercetin, but not other antioxidants. Chem Biol Interact. 2010; 186(3):275-9. DOI: 10.1016/j.cbi.2010.05.010. View
2.
Pastrana-Bonilla E, Akoh C, Sellappan S, Krewer G . Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem. 2003; 51(18):5497-503. DOI: 10.1021/jf030113c. View
3.
Aston J, Lodolce A, Shapiro N . Interaction between warfarin and cranberry juice. Pharmacotherapy. 2006; 26(9):1314-9. DOI: 10.1592/phco.26.9.1314. View
4.
Naranjo C, Busto U, Sellers E, Sandor P, Ruiz I, Roberts E . A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30(2):239-45. DOI: 10.1038/clpt.1981.154. View
5.
Di Bari L, Ripoli S, Pradhan S, Salvadori P . Interactions between quercetin and warfarin for albumin binding: A new eye on food/drug interference. Chirality. 2009; 22(6):593-6. DOI: 10.1002/chir.20794. View