Primary Ciliary Dyskinesia: An Update on New Diagnostic Modalities and Review of the Literature

Overview

Journal Pediatr Allergy Immunol Pulmonol

Specialties Allergy & Immunology
Pediatrics
Pulmonary Medicine

Date 2014 Jun 26

PMID 24963453

Citations 16

Authors

Rizwana Popatia

Kenan Haver

Alicia Casey

Affiliations

Soon will be listed here.

Abstract

Primary ciliary dyskinesia (PCD) is a genetic condition affecting approximately 1 in 15,000-20,000 individuals, and the majority of cases exhibit an autosomal recessive inheritance pattern. However, genetic heterogenicity is seen in PCD and reflects the complexity of ciliary structure and biogenesis. There have been many recent advances in the diagnosis and management of PCD in the last few years, including advanced genetic sequencing, nasal nitric oxide assay, and ciliary motility tests. This article focuses on the ultrastructure and pathophysiology of ciliary dyskinesias, along with a review of clinical features, screening, and diagnostic tests. It also reflects upon the diagnostic challenge caused by the diverse clinical presentation, which will be of great value to pediatricians for considering PCD in their differential list, henceforth leading to early recognition and management, along with awareness of the recent advances in the field of genetics and other techniques for diagnosis of this condition.

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