Functional Divergence in Gastrointestinal Microbiota in Physically-separated Genetically Identical Mice

Overview

Journal Sci Rep

Specialty Science

Date 2014 Jun 26

PMID 24961643

Citations 32

Authors

G B Rogers

J Kozlowska

J Keeble

K Metcalfe

M Fao

S E Dowd

A J Mason

M A McGuckin

K D Bruce

Affiliations

Soon will be listed here.

Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

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