Amplification of Both C-myc and C-raf-1 Oncogenes in a Human Osteosarcoma

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1989 Jan 1

PMID 2496060

Citations 13

Authors

S Ikeda

H Sumii

K Akiyama

S Watanabe

S Ito

H Inoue

H Takechi

G Tanabe

T Oda

Affiliations

Soon will be listed here.

Abstract

Fourteen human bone and soft part tumor tissues were screened by Southern blot hybridization using five oncogene probes (c-myc, c-K-ras, c-fos, c-raf-1, and N-myc). Amplification of c-myc was found in two osteosarcomas and one malignant fibrous histiocytoma. One of these osteosarcomas had amplified c-raf-1 gene. Rearrangement of the amplified gene was not observed. This is the first report of c-raf-1 amplification in human cancer tissues.

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