Examination of Daytime Sleepiness and Cognitive Performance Testing in Patients with Primary Insomnia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jun 25

PMID 24959897

Citations 12

Authors

Hong Liu

Dexi Wang

Yun Li

Zhe Li

Ying Zhang

Fei Lei

Lina Du

Xiangdong Tang

Affiliations

Soon will be listed here.

Abstract

Objective: While individuals with insomnia consistently complain of cognitive impairment, previous studies on the effect of insomnia on objective measures of cognitive function have obtained ambiguous results. The relationship between daytime sleepiness and cognitive manifestations in insomnia patients is not clear.

Methods: Thirty-six primary insomnia patients (PIPs) and 26 good sleep controls (GSCs) with age and gender matched manner were included in the study. Participants underwent an overnight polysomnography followed by a multiple sleep latency test (MSLT) and an examination of the attention network test (ANT). ANT reflected three attentional networks including alerting, orienting and executive control. According to whether accompanied with excessive daytime sleepiness (EDS), the insomnia group were subdivided into PIPs with EDS (n = 12, score on MSLT<10 min) and PIPs without EDS (n = 24, score on MSLT≥10 min).

Results: PIPs only performed worse on executive control function than GSCs in ANT. PIPs with EDS had longer overall reaction time (RT) related to PIPs without EDS. Further analyses with Pearson correlation analysis showed a significant negative correlation between the overall RT and MSLT latency in insomniacs (r = -0.444, p<0.01), whereas no such correlation was found in controls.

Conclusions: Results suggest that PIPs do show executive control function deficits compared with GSCs. Daytime sleepiness in terms of MSLT latency was associated with poor cognitive manifestations in patients with insomnia.

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References

Altena E, van der Werf Y, Strijers R, van Someren E . Sleep loss affects vigilance: effects of chronic insomnia and sleep therapy. J Sleep Res. 2008; 17(3):335-43. DOI: 10.1111/j.1365-2869.2008.00671.x. View

Buysse D, Reynolds 3rd C, Monk T, Hoch C, Yeager A, Kupfer D . Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep. 1991; 14(4):331-8. View

Adolfsdottir S, Sorensen L, Lundervold A . The attention network test: a characteristic pattern of deficits in children with ADHD. Behav Brain Funct. 2008; 4:9. PMC: 2265730. DOI: 10.1186/1744-9081-4-9. View

Fortier-Brochu E, Beaulieu-Bonneau S, Ivers H, Morin C . Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev. 2011; 16(1):83-94. DOI: 10.1016/j.smrv.2011.03.008. View

Fulda S, Schulz H . Cognitive dysfunction in sleep disorders. Sleep Med Rev. 2003; 5(6):423-445. DOI: 10.1053/smrv.2001.0157. View

Westlye L, Grydeland H, Walhovd K, Fjell A . Associations between regional cortical thickness and attentional networks as measured by the attention network test. Cereb Cortex. 2010; 21(2):345-56. DOI: 10.1093/cercor/bhq101. View

Finan P, Smith M . The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev. 2012; 17(3):173-83. PMC: 3519938. DOI: 10.1016/j.smrv.2012.03.003. View

Covassin N, de Zambotti M, Sarlo M, Tona G, Sarasso S, Stegagno L . Cognitive performance and cardiovascular markers of hyperarousal in primary insomnia. Int J Psychophysiol. 2011; 80(1):79-86. DOI: 10.1016/j.ijpsycho.2011.02.005. View

Li S, Arguelles L, Jiang F, Chen W, Jin X, Yan C . Sleep, school performance, and a school-based intervention among school-aged children: a sleep series study in China. PLoS One. 2013; 8(7):e67928. PMC: 3707878. DOI: 10.1371/journal.pone.0067928. View

10.

Bayard S, Croisier Langenier M, Cochen De Cock V, Scholz S, Dauvilliers Y . Executive control of attention in narcolepsy. PLoS One. 2012; 7(4):e33525. PMC: 3338809. DOI: 10.1371/journal.pone.0033525. View

11.

Gradisar M, Lack L, Richards H, Harris J, Gallasch J, Boundy M . The Flinders Fatigue Scale: preliminary psychometric properties and clinical sensitivity of a new scale for measuring daytime fatigue associated with insomnia. J Clin Sleep Med. 2008; 3(7):722-8. PMC: 2556916. View

12.

Neuhaus A, Urbanek C, Opgen-Rhein C, Hahn E, Ta T, Koehler S . Event-related potentials associated with Attention Network Test. Int J Psychophysiol. 2010; 76(2):72-9. DOI: 10.1016/j.ijpsycho.2010.02.005. View

13.

Brocki K, Clerkin S, Guise K, Fan J, Fossella J . Assessing the molecular genetics of the development of executive attention in children: focus on genetic pathways related to the anterior cingulate cortex and dopamine. Neuroscience. 2009; 164(1):241-6. PMC: 2792745. DOI: 10.1016/j.neuroscience.2009.01.029. View

14.

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

15.

Mendelson W, Garnett D, Gillin J, Weingartner H . The experience of insomnia and daytime and nighttime functioning. Psychiatry Res. 1984; 12(3):235-50. DOI: 10.1016/0165-1781(84)90029-5. View

16.

Carter C, Botvinick M, Cohen J . The contribution of the anterior cingulate cortex to executive processes in cognition. Rev Neurosci. 1999; 10(1):49-57. DOI: 10.1515/revneuro.1999.10.1.49. View

17.

Wang K, Fan J, Dong Y, Wang C, Lee T, Posner M . Selective impairment of attentional networks of orienting and executive control in schizophrenia. Schizophr Res. 2005; 78(2-3):235-41. DOI: 10.1016/j.schres.2005.01.019. View

18.

Lamond N, Jay S, Dorrian J, Ferguson S, Jones C, Dawson D . The dynamics of neurobehavioural recovery following sleep loss. J Sleep Res. 2007; 16(1):33-41. DOI: 10.1111/j.1365-2869.2007.00574.x. View

19.

Huang L, Zhou J, Li Z, Lei F, Tang X . Sleep perception and the multiple sleep latency test in patients with primary insomnia. J Sleep Res. 2012; 21(6):684-92. DOI: 10.1111/j.1365-2869.2012.01028.x. View

20.

OBrien L . The neurocognitive effects of sleep disruption in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2009; 18(4):813-23. DOI: 10.1016/j.chc.2009.04.008. View