Zinc Supplementation in Acute Diarrhea

Objective: To determine the effect of zinc supplementation on the duration of acute diarrhea in children.

Methods: A search was conducted in PubMed, the Cochrane Library database, China Biology Medicine (CBM), CNKI, VIP, and Wanfang Data to find studies on zinc supplementation for children with acute diarrhea from the date of establishment of the respective databases to June 2013. Clinical trials were included, and reviews or other types of studies were excluded. Considering the inclusion criteria, articles were evaluated by two individual investigators. The Cochrane Handbook 5.0.2 was used to evaluate the methodological quality. RevMan 5.2 software was used for meta-analysis. Heterogeneity of the included studies was tested to select a proper effect model. Measurement data were expressed as standard mean difference (SMD), weighted mean difference (WMD), and 95 % confidence interval (CI).

Results: A total of 860 relevant articles were found, and 8 randomized control trials that met the inclusion criteria were included. Meta-analysis showed a significant difference in the duration of acute diarrhea between treatment and control groups, with a WMD of -14.47 (95 % CI: -25.06 to -3.89; P = 0.007). However, significant heterogeneity was found among the studies. Sensitivity analysis and subgroup analyses based on admission condition, sample size and age group were also performed, for which heterogeneity cannot be completely eliminated.

Conclusions: Zinc supplementation can decrease the duration of acute diarrhea in children, but future studies should carry out a more thorough analysis in less heterogeneous subjects for a more definitive conclusion.