Effects of Overshadowing on Conditioned and Unconditioned Nausea in a Rotation Paradigm with Humans

Overview

Journal Exp Brain Res

Specialty Neurology

Date 2014 Jun 24

PMID 24954556

Citations 7

Authors

Ursula Stockhorst

Geoffrey Hall

Paul Enck

Sibylle Klosterhalfen

Affiliations

Soon will be listed here.

Abstract

We examine whether overshadowing by salient stimuli is effective in reducing the ability of a certain environment (the putative conditioned stimulus) to evoke conditioned nausea in healthy humans that experience nausea-evoking rotation (as the unconditioned stimulus, US) in that environment. Twenty-four rotation-susceptible subjects (12 males, 12 females) were randomly assigned to receive either overshadowing by salient tasting beverages (OS+), or a control treatment (a familiar beverage, water; OS-) prior to rotation on three consecutive days (acquisition). To control for taste experiences, the alternative beverage was consumed 12 h later in the home environment (OS+: water, OS-: salient beverage). At Day 4 (test), all subjects drank the familiar beverage (water) prior to rotation (US). Rotation was standardized as 2 × 1-min rotation/day. Nausea was determined by a 7-item symptom scale measuring symptom number (SN) prior to (anticipatory), immediately after, and 15 and 30 min after rotation and by the Nausea Profile (NP) questionnaire immediately after rotation. Cortisol and tumour necrosis factor (TNF)-α in saliva were sampled at the same time-points. SN and cortisol were also measured at home. Overshadowing reduced anticipatory (conditioned) SN. Post-rotation nausea (i.e. the unconditioned response) measured by the NP decreased within the OS+ group only. Anticipatory cortisol and TNF-α were not affected by overshadowing. Treatment × gender interactions manifested for post-rotation cortisol and TNF-α. Groups did not differ in SN and cortisol at home. Overshadowing is effective in reducing symptoms of anticipatory nausea and rotation-induced unconditioned nausea; its effect on endocrine and immunological parameters is gender specific. Its application in alleviation of anticipatory nausea in cancer patients is considered.

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References

Symonds M, Hall G . Postinjection suppression of drinking is modified by the presence of conditioned contextual cues: implications for both anticipatory and posttreatment nausea in humans. Anim Learn Behav. 2003; 30(4):355-62. DOI: 10.3758/bf03195960. View

Durlach P, Rescorla R . Potentiation rather than overshadowing in flavor-aversion learning: an analysis in terms of within-compound associations. J Exp Psychol Anim Behav Process. 1980; 6(2):175-87. View

Rohleder N, Otto B, Wolf J, Klose J, Kirschbaum C, Enck P . Sex-specific adaptation of endocrine and inflammatory responses to repeated nauseogenic body rotation. Psychoneuroendocrinology. 2005; 31(2):226-36. DOI: 10.1016/j.psyneuen.2005.07.004. View

Jordan K, Kasper C, Schmoll H . Chemotherapy-induced nausea and vomiting: current and new standards in the antiemetic prophylaxis and treatment. Eur J Cancer. 2005; 41(2):199-205. DOI: 10.1016/j.ejca.2004.09.026. View

Meissner K, Enck P, Muth E, Kellermann S, Klosterhalfen S . Cortisol levels predict motion sickness tolerance in women but not in men. Physiol Behav. 2009; 97(1):102-6. DOI: 10.1016/j.physbeh.2009.02.007. View

Watanobe H . Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-alpha, but not to interleukin-6, in the rat. Brain Res Bull. 2002; 57(2):151-5. DOI: 10.1016/s0361-9230(01)00735-3. View

Faul F, Erdfelder E, Lang A, Buchner A . G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007; 39(2):175-91. DOI: 10.3758/bf03193146. View

Rogers R, Van Meter M, Hermann G . Tumor necrosis factor potentiates central vagal afferent signaling by modulating ryanodine channels. J Neurosci. 2006; 26(49):12642-6. PMC: 6674848. DOI: 10.1523/JNEUROSCI.3530-06.2006. View

Boakes R, Tarrier N, Barnes B, Tattersall M . Prevalence of anticipatory nausea and other side-effects in cancer patients receiving chemotherapy. Eur J Cancer. 1993; 29A(6):866-70. DOI: 10.1016/s0959-8049(05)80427-7. View

10.

Dressendorfer R, Kirschbaum C, Rohde W, Stahl F, Strasburger C . Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol. 1992; 43(7):683-92. DOI: 10.1016/0960-0760(92)90294-s. View

11.

Haiderali A, Menditto L, Good M, Teitelbaum A, Wegner J . Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. population. Support Care Cancer. 2010; 19(6):843-51. DOI: 10.1007/s00520-010-0915-9. View

12.

Dalla C, Shors T . Sex differences in learning processes of classical and operant conditioning. Physiol Behav. 2009; 97(2):229-38. PMC: 2699937. DOI: 10.1016/j.physbeh.2009.02.035. View

13.

Aapro M, Molassiotis A, Olver I . Anticipatory nausea and vomiting. Support Care Cancer. 2004; 13(2):117-21. DOI: 10.1007/s00520-004-0745-8. View

14.

Klosterhalfen S, Ruttgers A, Krumrey E, Otto B, Stockhorst U, Riepl R . Pavlovian conditioning of taste aversion using a motion sickness paradigm. Psychosom Med. 2000; 62(5):671-7. DOI: 10.1097/00006842-200009000-00011. View

15.

Aapro M, Kirchner V, Terrey J . The incidence of anticipatory nausea and vomiting after repeat cycle chemotherapy: the effect of granisetron. Br J Cancer. 1994; 69(5):957-60. PMC: 1968891. DOI: 10.1038/bjc.1994.185. View

16.

Stockhorst U, Klosterhalfen S, Klosterhalfen W, Winkelmann M, Steingrueber H . Anticipatory nausea in cancer patients receiving chemotherapy: classical conditioning etiology and therapeutical implications. Integr Physiol Behav Sci. 1993; 28(2):177-81. DOI: 10.1007/BF02691224. View

17.

Dantzer R . Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci. 2002; 933:222-34. DOI: 10.1111/j.1749-6632.2001.tb05827.x. View

18.

Andrykowski M, Jacobsen P, Marks E, Gorfinkle K, Hakes T, Kaufman R . Prevalence, predictors, and course of anticipatory nausea in women receiving adjuvant chemotherapy for breast cancer. Cancer. 1988; 62(12):2607-13. DOI: 10.1002/1097-0142(19881215)62:12<2607::aid-cncr2820621226>3.0.co;2-s. View

19.

Stockhorst U, Korholz D, Gobel U, Schneider M, Steingruber H, Klosterhalfen S . Anticipatory symptoms and anticipatory immune responses in pediatric cancer patients receiving chemotherapy: features of a classically conditioned response?. Brain Behav Immun. 2000; 14(3):198-218. DOI: 10.1006/brbi.1999.0581. View

20.

Klosterhalfen S, Kellermann S, Stockhorst U, Wolf J, Kirschbaum C, Hall G . Latent inhibition of rotation chair-induced nausea in healthy male and female volunteers. Psychosom Med. 2005; 67(2):335-40. DOI: 10.1097/01.psy.0000156930.00201.e0. View