Role of the Gut in Modulating Lipoprotein Metabolism

Overview

Journal Curr Cardiol Rep

Publisher Current Science

Specialty Cardiology & Vascular Diseases

Date 2014 Jun 22

PMID 24950675

Citations 11

Authors

Alan A Hennessy

R Paul Ross

Gerald F Fitzgerald

Noel Caplice

Catherine Stanton

Affiliations

Soon will be listed here.

Abstract

The intestinal production of lipoproteins is one of the key processes by which the body prepares dietary lipid for dissemination to locations throughout the body where they are required. Paramount to this is the relationship between dietary lipid and the enterocytes that line the gut, along with the processes which prepare this lipid for efficient uptake by these cells. These include those which occur in the mouth and stomach along with those which occur within the intestinal lumen itself. Additionally, the interplay between digested lipid, dual avenues for lipid uptake by enterocytes (passive and lipid transporter proteins), a system of intercellular lipid resynthesis and transport, and a complex system of lipoprotein synthesis yield a system open to significant modulation. In this review, we will attempt to outline the processes of lipid digestion, lipoprotein synthesis and the exogenous and endogenous factors which exert their influence.

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References

Wilde P, Chu B . Interfacial & colloidal aspects of lipid digestion. Adv Colloid Interface Sci. 2011; 165(1):14-22. DOI: 10.1016/j.cis.2011.02.004. View

Kindel T, Lee D, Tso P . The mechanism of the formation and secretion of chylomicrons. Atheroscler Suppl. 2010; 11(1):11-6. DOI: 10.1016/j.atherosclerosissup.2010.03.003. View

MATTSON F, BECK L . The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides. J Biol Chem. 1956; 219(2):735-40. View

Duan R, Nyberg L, Nilsson A . Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics. Biochim Biophys Acta. 1995; 1259(1):49-55. DOI: 10.1016/0005-2760(95)00137-2. View

Lu S, Yao Y, Meng S, Cheng X, Black D . Overexpression of apolipoprotein A-IV enhances lipid transport in newborn swine intestinal epithelial cells. J Biol Chem. 2002; 277(35):31929-37. DOI: 10.1074/jbc.M201418200. View

Trigatti B, Anderson R, Gerber G . Identification of caveolin-1 as a fatty acid binding protein. Biochem Biophys Res Commun. 1999; 255(1):34-9. DOI: 10.1006/bbrc.1998.0123. View

Borgstrom B . Importance of phospholipids, pancreatic phospholipase A2, and fatty acid for the digestion of dietary fat: in vitro experiments with the porcine enzymes. Gastroenterology. 1980; 78(5 Pt 1):954-62. View

Konturek J, Thor P, Maczka M, Stoll R, Domschke W, Konturek S . Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients. Scand J Gastroenterol. 1994; 29(7):583-90. DOI: 10.3109/00365529409092476. View

Salas-Salvado J, Marquez-Sandoval F, Bullo M . Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr. 2006; 46(6):479-88. DOI: 10.1080/10408390600723953. View

10.

Porez G, Prawitt J, Gross B, Staels B . Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res. 2012; 53(9):1723-37. PMC: 3413216. DOI: 10.1194/jlr.R024794. View

11.

Coakley M, Ross R, Nordgren M, Fitzgerald G, Devery R, Stanton C . Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. J Appl Microbiol. 2002; 94(1):138-45. DOI: 10.1046/j.1365-2672.2003.01814.x. View

12.

Kerfelec B, Allouche M, Colin D, Van Eyck M, Brasseur R, Thomas A . Computational study of colipase interaction with lipid droplets and bile salt micelles. Proteins. 2008; 73(4):828-38. DOI: 10.1002/prot.22109. View

13.

DAgostino D, Cordle R, Kullman J, Erlanson-Albertsson C, Muglia L, Lowe M . Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2001; 277(9):7170-7. PMC: 2528063. DOI: 10.1074/jbc.M108328200. View

14.

Duan R, Nilsson A . Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development. Prog Lipid Res. 2008; 48(1):62-72. DOI: 10.1016/j.plipres.2008.04.003. View

15.

Xiao C, Bandsma R, Dash S, Szeto L, Lewis G . Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol. 2012; 32(6):1513-9. DOI: 10.1161/ATVBAHA.112.246207. View

16.

Freedman S, SCHEELE G . Acid-base interactions during exocrine pancreatic secretion. Primary role for ductal bicarbonate in acinar lumen function. Ann N Y Acad Sci. 1994; 713:199-206. DOI: 10.1111/j.1749-6632.1994.tb44066.x. View

17.

Hsieh J, Longuet C, Maida A, Bahrami J, Xu E, Baker C . Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36. Gastroenterology. 2009; 137(3):997-1005, 1005.e1-4. DOI: 10.1053/j.gastro.2009.05.051. View

18.

Liddle R, Morita E, Conrad C, Williams J . Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest. 1986; 77(3):992-6. PMC: 423501. DOI: 10.1172/JCI112401. View

19.

Chen M, Yang Y, BRAUNSTEIN E, Georgeson K, Harmon C . Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab. 2001; 281(5):E916-23. DOI: 10.1152/ajpendo.2001.281.5.E916. View

20.

Nilsson A, Duan R . Absorption and lipoprotein transport of sphingomyelin. J Lipid Res. 2005; 47(1):154-71. DOI: 10.1194/jlr.M500357-JLR200. View