Childhood B-acute Lymphoblastic Leukemia: a Genetic Update

Overview

Journal Exp Hematol Oncol

Publisher Biomed Central

Specialty Hematology

Date 2014 Jun 21

PMID 24949228

Citations 55

Authors

Jennifer S Woo

Michael O Alberti

Carlos A Tirado

Affiliations

Soon will be listed here.

Abstract

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based technologies and next-generation sequencing (NGS) techniques have revealed exciting insights into the genetic basis of this disease, with the hopes of developing individualized treatment plans for affected children. In this comprehensive review, we discuss our current understanding of childhood (pediatric) B-ALL and highlight the most recent genetic advances and their therapeutic implications.

Citing Articles

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