Death by Water: Precautionary Water Submersion for Intravitreal Injection of Retinoblastoma Eyes

Overview

Journal Open Ophthalmol J

Publisher Bentham Open

Specialty Ophthalmology

Date 2014 Jun 21

PMID 24949111

Citations 7

Authors

Jasmine H Francis

Xiaoliang L Xu

Y Pierre Gobin

Brian P Marr

Scott E Brodie

David H Abramson

Affiliations

Soon will be listed here.

Abstract

There is growing interest in intravitreal injections of chemotherapy for retinoblastoma. However, concerns for potential tumor seeding through the needle track has prompted the use of risk-reducing precautionary methods. Presented here is a novel technique, which can be easily replicated, requires minimal sophisticated equipment and with laboratory data supporting its concept. Sterile distilled water submersion for 3 minutes renders retinoblastoma cells nonviable and can be employed as a precautionary method following intravitreal injection in the technique described here.

Citing Articles

Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand.

Rojanaporn D, Attaseth T, Dieosuthichat W, Leelawongs K, Pakakasama S, Anurathapan U J Ophthalmol. 2020; 2020:4231841.

PMID: 33005446 PMC: 7508219. DOI: 10.1155/2020/4231841.

Precision Intravitreal Chemotherapy for Localized Vitreous Seeding of Retinoblastoma.

Yu M, Dalvin L, Welch R, Shields C Ocul Oncol Pathol. 2019; 5(4):284-289.

PMID: 31367592 PMC: 6615328. DOI: 10.1159/000491432.

Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy.

Francis J, Abramson D, Ji X, Shields C, Teixeira L, Schefler A JAMA Ophthalmol. 2017; 135(12):1426-1429.

PMID: 29098285 PMC: 6583521. DOI: 10.1001/jamaophthalmol.2017.4600.

Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment.

Francis J, Habib L, Abramson D Adv Ophthalmol Optom. 2017; 2(1):177-195.

PMID: 29034355 PMC: 5635842. DOI: 10.1016/j.yaoo.2017.03.008.

Efficacy and Toxicity of Intravitreous Chemotherapy for Retinoblastoma: Four-Year Experience.

Francis J, Brodie S, Marr B, Zabor E, Mondesire-Crump I, Abramson D Ophthalmology. 2017; 124(4):488-495.

PMID: 28089679 PMC: 5441308. DOI: 10.1016/j.ophtha.2016.12.015.

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