Inflammasomes and Intestinal Homeostasis: Regulating and Connecting Infection, Inflammation and the Microbiota

Overview

Journal Int Immunol

Specialty Allergy & Immunology

Date 2014 Jun 21

PMID 24948595

Citations 28

Authors

Nicola Gagliani

Noah W Palm

Marcel R de Zoete

Richard A Flavell

Affiliations

Soon will be listed here.

Abstract

Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.

Citing Articles

Activation of GABAR Attenuates Intestinal Inflammation by Reducing Oxidative Stress through Modulating the TLR4/MyD88/NLRP3 Pathway and Gut Microbiota Abundance.

Deng Z, Li D, Wang L, Lan J, Wang J, Ma Y Antioxidants (Basel). 2024; 13(9).

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Effects of gut microbiota on neurodegenerative diseases.

Khatoon S, Kalam N, Rashid S, Bano G Front Aging Neurosci. 2023; 15:1145241.

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Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells.

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Role of the duodenal microbiota in functional dyspepsia.

Brown G, Hoedt E, Keely S, Shah A, Walker M, Holtmann G Neurogastroenterol Motil. 2022; 34(11):e14372.

PMID: 35403776 PMC: 9786680. DOI: 10.1111/nmo.14372.

Implications of Gut Microbiota in Neurodegenerative Diseases.

Zhang H, Chen Y, Wang Z, Xie G, Liu M, Yuan B Front Immunol. 2022; 13:785644.

PMID: 35237258 PMC: 8882587. DOI: 10.3389/fimmu.2022.785644.

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