[Gender-specific Differences in Comorbidities of Rheumatoid Arthritis]

Overview

Journal Z Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2014 Jun 19

PMID 24939007

Citations 14

Authors

K Albrecht

Affiliations

Soon will be listed here.

Abstract

Background: Comorbidities play an important role in the course and therapy of rheumatoid arthritis (RA). Sex-specific aspects are observed with regard to prevalence and manifestation of RA-related comorbidities.

Aim: A summary of current insights into sex and gender-related aspects of frequent comorbidities in RA is given.

Material And Methods: National data were analyzed and literature findings from meta-analyses, observational studies and reviews with regard to gender and RA-associated comorbidities are presented.

Results: There are gender-specific differences in the prevalence of comorbidities of RA. Depression, fibromyalgia and hypothyroidism are more frequent in women than in men, whereas cardiovascular diseases and diabetes are more common in men. Osteoarthritis and osteoporosis are frequent in both sexes.

Conclusion: Sex and gender-specific aspects should be taken into consideration in the diagnostics and treatment of RA-related comorbidities.

Citing Articles

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Topless R, Phipps-Green A, Leask M, Dalbeth N, Stamp L, Robinson P ACR Open Rheumatol. 2021; 3(5):333-340.

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References

Mercer L, Davies R, Galloway J, Low A, Lunt M, Dixon W . Risk of cancer in patients receiving non-biologic disease-modifying therapy for rheumatoid arthritis compared with the UK general population. Rheumatology (Oxford). 2012; 52(1):91-8. PMC: 3521445. DOI: 10.1093/rheumatology/kes350. View

Humphreys J, Verstappen S, Mirjafari H, Bunn D, Lunt M, Bruce I . Association of morbid obesity with disability in early inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Care Res (Hoboken). 2012; 65(1):122-6. PMC: 3568899. DOI: 10.1002/acr.21722. View

Solomon D, Karlson E, Rimm E, Cannuscio C, Mandl L, Manson J . Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation. 2003; 107(9):1303-7. DOI: 10.1161/01.cir.0000054612.26458.b2. View

Nicola P, Maradit-Kremers H, Roger V, Jacobsen S, Crowson C, Ballman K . The risk of congestive heart failure in rheumatoid arthritis: a population-based study over 46 years. Arthritis Rheum. 2005; 52(2):412-20. DOI: 10.1002/art.20855. View

McCoy S, Crowson C, Gabriel S, Matteson E . Hypothyroidism as a risk factor for development of cardiovascular disease in patients with rheumatoid arthritis. J Rheumatol. 2012; 39(5):954-8. PMC: 3518421. DOI: 10.3899/jrheum.111076. View

Nannini C, Medina-Velasquez Y, Achenbach S, Crowson C, Ryu J, Vassallo R . Incidence and mortality of obstructive lung disease in rheumatoid arthritis: a population-based study. Arthritis Care Res (Hoboken). 2013; 65(8):1243-50. PMC: 4017238. DOI: 10.1002/acr.21986. View

Raaschou P, Simard J, Holmqvist M, Askling J . Rheumatoid arthritis, anti-tumour necrosis factor therapy, and risk of malignant melanoma: nationwide population based prospective cohort study from Sweden. BMJ. 2013; 346:f1939. DOI: 10.1136/bmj.f1939. View

Przygodzka M, Filipowicz-Sosnowska A . Prevalence of thyroid diseases and antithyroid antibodies in women with rheumatoid arthritis. Pol Arch Med Wewn. 2009; 119(1-2):39-43. View

Wolfe F, Michaud K . Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize ra patients with fibromyalgia. J Rheumatol. 2004; 31(4):695-700. View

10.

Peters M, Symmons D, McCarey D, Dijkmans B, Nicola P, Kvien T . EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis. 2009; 69(2):325-31. DOI: 10.1136/ard.2009.113696. View

11.

Amin S . Male osteoporosis: epidemiology and pathophysiology. Curr Osteoporos Rep. 2005; 1(2):71-7. DOI: 10.1007/s11914-003-0012-9. View

12.

Fuchs J, Rabenberg M, Scheidt-Nave C . [Prevalence of selected musculoskeletal conditions in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013; 56(5-6):678-86. DOI: 10.1007/s00103-013-1687-4. View

13.

Kung M, Stork S, Angermann C . [Cardiovascular comorbidity in rheumatic disease. Does sex play a role?]. Herz. 2005; 30(6):512-21. DOI: 10.1007/s00059-005-2717-2. View

14.

Dougados M, Soubrier M, Antunez A, Balint P, Balsa A, Buch M . Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2013; 73(1):62-8. PMC: 3888623. DOI: 10.1136/annrheumdis-2013-204223. View

15.

Wallberg-Jonsson S, Ohman M, Dahlqvist S . Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden. J Rheumatol. 1997; 24(3):445-51. View

16.

Crowson C, Matteson E, Davis 3rd J, Gabriel S . Contribution of obesity to the rise in incidence of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012; 65(1):71-7. PMC: 3707391. DOI: 10.1002/acr.21660. View

17.

van den Hoek J, Roorda L, Boshuizen H, van Hees J, Rupp I, Tijhuis G . Long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis: a longitudinal study. Arthritis Care Res (Hoboken). 2013; 65(7):1157-65. DOI: 10.1002/acr.21950. View

18.

Norton S, Koduri G, Nikiphorou E, Dixey J, Williams P, Young A . A study of baseline prevalence and cumulative incidence of comorbidity and extra-articular manifestations in RA and their impact on outcome. Rheumatology (Oxford). 2012; 52(1):99-110. DOI: 10.1093/rheumatology/kes262. View

19.

Oelzner P, Schwabe A, Lehmann G, Eidner T, Franke S, Wolf G . Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis. Rheumatol Int. 2008; 28(11):1143-50. DOI: 10.1007/s00296-008-0576-x. View

20.

Heberlein I, Demary W, Bloching H, Braun J, Buttgereit F, Dreher R . [Prophylaxis and treatment of osteoporosis in patients with rheumatoid arthritis (ORA study)]. Z Rheumatol. 2011; 70(9):793-8, 800-2. DOI: 10.1007/s00393-011-0872-9. View