Mixed Lineage Leukemia-septin 5 Fusion Transcript in Adult Acute Myeloid Leukemia with T(11;22)(q23;q11.2): A Case Report

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Jun 17

PMID 24932261

Citations 3

Authors

Wen Gao

Tong Wang

Yin Wu

Hong Xing Liu

Yan Chen Li

Wen Ming Chen

Affiliations

Soon will be listed here.

Abstract

The current report presents a case of acute myeloid leukemia (AML) in a 32-year-old male. Cytogenetic analysis showed that the karyotype of the bone marrow cells was as follows: 46,XY,t(11;22)(q23;q11.2)[13]/46,X,-Y,+10,t(11;22)(q23;q11.2)[7]/47,XY,+10,t(11;22)(q23;q11.2)[1]/46,XY[1]. Fluorescence in situ hybridization analysis using a mixed lineage leukemia (MLL)-specific probe showed a split in the MLL gene. Reverse transcription polymerase chain reaction (PCR) analysis demonstrated an MLL-septin 5 (SEPT5) fusion transcript in the patient. Nucleotide sequencing analysis of the PCR product confirmed the fusion between the MLL exon 9 and SEPT5 exon 3, and the product was 521 bp in length. The present study reviewed the clinical and molecular features of the AML with an MLL-SEPT5 fusion gene.

Citing Articles

MLL-SEPT5 Fusion Transcript in Myelodysplastic Syndrome Patient With t(11;22)(q23;q11).

Zou D, Chen Y, Wu N, Zhang Y, Ouyang G, Mu Q Front Med (Lausanne). 2022; 8:783229.

PMID: 35004749 PMC: 8729882. DOI: 10.3389/fmed.2021.783229.

Acute myeloid leukemia with translocation: A case report and review of the literature.

Elzamly S, Chavali S, Tonk V, Tonk S, Gaur S, Tarango D SAGE Open Med Case Rep. 2018; 6:2050313X17750334.

PMID: 29326822 PMC: 5758965. DOI: 10.1177/2050313X17750334.

MLL-SEPT5 Fusion Transcript in Two de novo Acute Myeloid Leukemia Patients With t(11;22)(q23;q11).

Wang N, Wu X, Sheng G, Ma L, Wen L, Yao H Ann Lab Med. 2016; 36(5):501-3.

PMID: 27374720 PMC: 4940498. DOI: 10.3343/alm.2016.36.5.501.

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