DNA Copy Number Alterations in Pleomorphic Leiomyosarcoma: A Case Report

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Jun 17

PMID 24932246

Authors

Masahiko Kanamori

Taketoshi Yasuda

Shigeharu Nogami

Kayo Suzuki

Takeshi Hori

Affiliations

Soon will be listed here.

Abstract

Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (/) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.

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