MITA/STING: a Central and Multifaceted Mediator in Innate Immune Response

Overview

Journal Cytokine Growth Factor Rev

Date 2014 Jun 16

PMID 24929887

Citations 39

Authors

Yong Ran

Hong-Bing Shu

Yan-Yi Wang

Affiliations

Soon will be listed here.

Abstract

The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive.

Citing Articles

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