Evaluation of the Role of Dynamic Contrast-enhanced MR Imaging for Patients with BI-RADS 3-4 Microcalcifications

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jun 14

PMID 24927476

Citations 8

Authors

Yanni Jiang

Jianjuan Lou

Siqi Wang

Yi Zhao

Cong Wang

Dehang Wang

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of study was to prospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging in the differentiation of malignant lesions from benign ones in patients with BI-RADS 3-4 microcalcifications detected by mammography.

Materials And Methods: 93 women with 100 microcalcifications had undergone breast MRI from June 2010 to July 2013. Subsequently, 91 received open biopsy and 2 received stereotactic vacuum-assisted biopsy. All results were compared with histological findings. The PPV, NPV and area under curve (AUC) of the mammography and breast MRI were calculated.

Results: There were 31 (31.0%) BI-RADS 3 microcalcifications and 69 (69.0%) BI-RADS 4. The PPV and NPV of mammography is 65.2% (45/69) and 90.3% (28/31). The PPV and NPV of breast MRI was 90.2% (46/51) and 95.9% (47/49). Among 31 BI-RADS 3 microcalcifications, the PPV and NPV of breast MRI was 100% (3/3) and 100% (28/28). Among 69 BI-RADS 4 microcalcifications, the PPV and NPV of breast MRI was 89.6% (43/48) and 90.5% (19/21). The AUC of mammography and breast MRI assessment were 0.738 (95% CI, 0.639-0.837) and 0.931 (95% CI, 0.874-0.988) (p<0.05).

Conclusion: Dynamic contrast-enhanced MR imaging of breast is able to be applied to predict the risk of malignance before follow-up for BI-RADS 3 microcalcifications and biopsy for BI-RADS 4 microcalcifications.

Citing Articles

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Optimal Selection of Imaging Examination for Lymph Node Detection of Breast Cancer With Different Molecular Subtypes.

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A New Application of Multimodality Radiomics Improves Diagnostic Accuracy of Nonpalpable Breast Lesions in Patients with Microcalcifications-Only in Mammography.

Chen S, Guan X, Shu Z, Li Y, Cao W, Dong F Med Sci Monit. 2019; 25:9786-9793.

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Fan W, Chen X, Cheng F, Cheng Y, Xu T, Zhu W Medicine (Baltimore). 2018; 97(4):e9666.

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MRI for the assessment of malignancy in BI-RADS 4 mammographic microcalcifications.

Bennani-Baiti B, Dietzel M, Baltzer P PLoS One. 2017; 12(11):e0188679.

PMID: 29190656 PMC: 5708819. DOI: 10.1371/journal.pone.0188679.

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