Inhibits the Growth of Pathogenic Fungi: and Studies

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2014 Jun 14

PMID 24926335

Citations 4

Authors

Lingqing Xu

Feng Wang

Yin Shen

Hongyan Hou

Weiyong Liu

Cailin Liu

Cui Jian

Yue Wang

Mingyue Sun

Ziyong Sun

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to investigate the inhibitory effect of (PA) on pathogenic fungi, including (CA), (CT), (CG), (CP) and (CK), and . In total, 24 PA strains were collected from clinical specimens and identified by Gram staining, oxidase production and the API 20NE system. Cross-streak, disk diffusion and co-culture methods were used to observe the inhibitory effect of PA. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used to analyze differences in the bacterial proteins of PA. A blood infection model in mice was used to evaluate the effect of PA on fungi . The and results demonstrated that a number of PA isolates exhibited a marked inhibitory effect on pathogenic fungi, including CA, CT, CP, CG and CK, while other PA strains exhibited no effect. Therefore, PA exhibits an inhibitory effect on pathogenic fungi and this activity may be important in the treatment of patients. It was hypothesized that PA secretes various types of proteins to suppress the growth of fungal filaments, which subsequently inhibits pathogenic fungi.

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