A Biocompatible Alkene Hydrogenation Merges Organic Synthesis with Microbial Metabolism

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2014 Jun 12

PMID 24916924

Citations 18

Authors

Gopal Sirasani

Liuchuan Tong

Emily P Balskus

Affiliations

Soon will be listed here.

Abstract

Organic chemists and metabolic engineers use orthogonal technologies to construct essential small molecules such as pharmaceuticals and commodity chemicals. While chemists have leveraged the unique capabilities of biological catalysts for small-molecule production, metabolic engineers have not likewise integrated reactions from organic synthesis with the metabolism of living organisms. Reported herein is a method for alkene hydrogenation which utilizes a palladium catalyst and hydrogen gas generated directly by a living microorganism. This biocompatible transformation, which requires both catalyst and microbe, and can be used on a preparative scale, represents a new strategy for chemical synthesis that combines organic chemistry and metabolic engineering.

Citing Articles

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