Daily Variations in the Glycerol-3-phosphate Dehydrogenase Isoforms Expression in Triatoma Infestans Flight Muscles

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2014 Jun 11

PMID 24914000

Citations 1

Authors

Maria M Stroppa

Carlota S Carriazo

Nelia M Gerez de Burgos

Beatriz A Garcia

Affiliations

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Abstract

Triatoma infestans, the main vector of Chagas disease, is a blood-sucking insect. Flight dispersal of adults is the most important mechanism for reinfestation of houses after insecticide spraying. Flight muscles have two glycerol-3-phosphate dehydrogenase (GPDH) isoforms: GPDH-1 is involved in flight metabolism and GPDH-2 provides lipid precursors. In this study, we explored the profile of GPDH expression in females and males adult flight muscles under light/dark cycle, constant light, and constant dark conditions. Under constant dark conditions, GPDH-1 flight muscles of T. infestans showed a rhythmic pattern of transcription synchronous with a rhythmic profile of activity suggesting regulation by the endogenous circadian clock. Otherwise, the GPDH-2 expression analysis showed no regulation by the endogenous clock, but showed that an external factor, such as the dark/light period, was necessary for synchronization of GPDH-2 transcription and activity.

Citing Articles

Clock Gene in the Chagas Disease Vector (Hemiptera: Reduviidae).

Stroppa M, Gimenez I, Garcia B Am J Trop Med Hyg. 2017; 98(2):468-474.

PMID: 29260645 PMC: 5929179. DOI: 10.4269/ajtmh.17-0147.

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