Home- Versus Hospital-based Phototherapy for the Treatment of Non-haemolytic Jaundice in Infants at More Than 37 Weeks' Gestation

Overview

Journal Cochrane Database Syst Rev

Publisher Wiley

Specialties General Medicine
Health Services

Date 2014 Jun 11

PMID 24913724

Citations 10

Authors

Ujjwala S Malwade

Luke A Jardine

Affiliations

Soon will be listed here.

Abstract

Background: Phototherapy is commonly used for the treatment of neonatal jaundice, and home-based phototherapy is now being used in certain centres. Home-based phototherapy offers possible advantages by avoiding prolonged hospital admissions, promoting mother-infant bonding and reducing hospitalisation costs. Potential problems include increased duration of phototherapy, increased readmission to hospital and increased risk of bilirubin encephalopathy.

Objectives: To compare exclusively home-based versus exclusively hospital-based phototherapy or a combination of home- and hospital-based phototherapy for the management of non-haemolytic jaundice in term infants up to 28 days of age. We planned to include specific subgroups for duration in hospital, method of phototherapy and criteria for readiness for discharge.

Search Methods: We searched the Cochrane Neonatal Review Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) January 2013, Issue 1, part of The Cochrane Library, MEDLINE (from 1966 to 15 February 2013), CINAHL (from 1982 to 15 February 2013) and EMBASE (from 1988 to 15 February 2013). We searched for abstracts from the Pediatric Academic Societies' Annual Meetings 2000 to 2013. We searched for ongoing trials on the following websites: ClinicalTrials.gov (http://clinicaltrials.gov/) and Current Controlled Trials (http://controlled-trials.com/).

Selection Criteria: Randomised and quasi-randomised studies comparing term infants who received phototherapy exclusively at home versus phototherapy exclusively in the hospital or a combination of the two for non-haemolytic jaundice.

Data Collection And Analysis: Two review authors independently assessed trial quality and extracted data.

Main Results: No studies that met the predefined eligibility criteria were identified.

Authors' Conclusions: No high-quality evidence is currently available to support or refute the practice of home-based phototherapy for non-haemolytic jaundice in infants at more than 37 weeks' gestation.

Citing Articles

Illuminating Progress: A Comprehensive Review of the Evolution of Phototherapy for Neonatal Hyperbilirubinemia.

Patel A, Vagha J, Meshram R, Taksande A, Khandelwal R, Jain A Cureus. 2024; 16(3):e55608.

PMID: 38586621 PMC: 10995653. DOI: 10.7759/cureus.55608.

Efficacy of home phototherapy versus inpatient phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis.

Li R, Li T, Yan X, Feng J, Yu Z, Chen C Ital J Pediatr. 2024; 50(1):37.

PMID: 38433210 PMC: 10910825. DOI: 10.1186/s13052-024-01613-0.

The cost-effectiveness of home phototherapy for hyperbilirubinemia in neonates: results from a randomized controlled trial.

Pettersson M, Ryen L, Eriksson M, Ohlin A Sci Rep. 2023; 13(1):10727.

PMID: 37400561 PMC: 10317991. DOI: 10.1038/s41598-023-37684-y.

Leveraging Predictive Pharmacometrics-Based Algorithms to Enhance Perinatal Care-Application to Neonatal Jaundice.

Koch G, Wilbaux M, Kasser S, Schumacher K, Steffens B, Wellmann S Front Pharmacol. 2022; 13:842548.

PMID: 36034866 PMC: 9402995. DOI: 10.3389/fphar.2022.842548.

Pilot study of home phototherapy for neonatal jaundice monitored in maternity ward during the enforced Italy-wide COVID-19 national lockdown.

Zanardo V, Guerrini P, Sandri A, Ramon C, Severino L, Garani G Eur J Pediatr. 2022; 181(9):3523-3529.

PMID: 35838779 PMC: 9283816. DOI: 10.1007/s00431-022-04557-x.

References

Hansen T . Kernicterus in term and near-term infants--the specter walks again. Acta Paediatr. 2000; 89(10):1155-7. DOI: 10.1080/080352500750027484. View

Kumar P, Chawla D, Deorari A . Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst Rev. 2011; (12):CD007969. PMC: 6885069. DOI: 10.1002/14651858.CD007969.pub2. View

Mreihil K, McDonagh A, Nakstad B, Hansen T . Early isomerization of bilirubin in phototherapy of neonatal jaundice. Pediatr Res. 2010; 67(6):656-9. DOI: 10.1203/PDR.0b013e3181dcedc0. View

Zainab K, Adlina S . Effectiveness of home versus hospital phototherapy for term infants with uncomplicated hyperbilirubinemia: a pilot study in Pahang, Malaysia. Med J Malaysia. 2005; 59(3):395-401. View

. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004; 114(1):297-316. DOI: 10.1542/peds.114.1.297. View

Bhutani V . Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2011; 128(4):e1046-52. PMC: 11412217. DOI: 10.1542/peds.2011-1494. View

Keren R, Tremont K, Luan X, Cnaan A . Visual assessment of jaundice in term and late preterm infants. Arch Dis Child Fetal Neonatal Ed. 2009; 94(5):F317-22. DOI: 10.1136/adc.2008.150714. View

Mills J, Tudehope D . Fibreoptic phototherapy for neonatal jaundice. Cochrane Database Syst Rev. 2001; (1):CD002060. PMC: 7025799. DOI: 10.1002/14651858.CD002060. View

Eggert L, Pollary R, Folland D, Jung A . Home phototherapy treatment of neonatal jaundice. Pediatrics. 1985; 76(4):579-84. View

10.

Moerschel S, Cianciaruso L, Tracy L . A practical approach to neonatal jaundice. Am Fam Physician. 2008; 77(9):1255-62. View

11.

Kumar P, Murki S, Malik G, Chawla D, Deorari A, Karthi N . Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial. Indian Pediatr. 2009; 47(2):131-7. DOI: 10.1007/s13312-010-0020-7. View

12.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

13.

Jackson C, Tudehope D, Willis L, Law T, Venz J . Home phototherapy for neonatal jaundice--technology and teamwork meeting consumer and service need. Aust Health Rev. 2000; 23(2):162-8. DOI: 10.1071/ah000162. View

14.

Grabert B, Wardwell C, Harburg S . Home phototherapy. An alternative to prolonged hospitalization of the full-term, well newborn. Clin Pediatr (Phila). 1986; 25(6):291-4. DOI: 10.1177/000992288602500601. View

15.

Ip S, Chung M, Kulig J, OBrien R, Sege R, Glicken S . An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004; 114(1):e130-53. DOI: 10.1542/peds.114.1.e130. View

16.

Slater L, Brewer M . Home versus hospital phototherapy for term infants with hyperbilirubinemia: a comparative study. Pediatrics. 1984; 73(4):515-9. View