Adenovirus: Current Epidemiology and Emerging Approaches to Prevention and Treatment

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2014 Jun 9

PMID 24908344

Citations 50

Authors

Uriel Sandkovsky

Luciano Vargas

Diana F Florescu

Affiliations

Soon will be listed here.

Abstract

Infections caused by adenoviruses are associated with significant morbidity and mortality in both hematopoietic stem cell and solid organ transplant recipients. The risk seems to be highest in allogeneic hematopoietic stem cell transplant recipients as well as heart, lung and small-bowel transplant recipients. Management of these infections may be difficult and includes reduction of immunosuppression whenever possible combined sometimes with antiviral therapy (mainly cidofovir). The currently available antiviral therapy is limited by the need for intravenous administration, potentially significant renal and hematologic toxicities. New emerging therapies such as brincidofovir and transfusion of adenovirus-specific T-lymphocytes may increase the available armamentarium for these potentially life-threatening infections.

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References

Schilham M, Claas E, van Zaane W, Heemskerk B, Vossen J, Lankester A . High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis. 2002; 35(5):526-32. DOI: 10.1086/341770. View

Abinun M, Flood T, Cant A, Veys P, Gennery A, Foster H . Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007). Mol Immunol. 2009; 47(1):46-51. DOI: 10.1016/j.molimm.2008.12.029. View

Matthes-Martin S, Boztug H, Lion T . Diagnosis and treatment of adenovirus infection in immunocompromised patients. Expert Rev Anti Infect Ther. 2013; 11(10):1017-28. DOI: 10.1586/14787210.2013.836964. View

Ziring D, Tran R, Edelstein S, McDiarmid S, Gajjar N, Cortina G . Infectious enteritis after intestinal transplantation: incidence, timing, and outcome. Transplantation. 2005; 79(6):702-9. DOI: 10.1097/01.tp.0000154911.15693.80. View

Moulik M, Breinholt J, Dreyer W, Kearney D, Price J, Clunie S . Viral endomyocardial infection is an independent predictor and potentially treatable risk factor for graft loss and coronary vasculopathy in pediatric cardiac transplant recipients. J Am Coll Cardiol. 2010; 56(7):582-92. PMC: 2963018. DOI: 10.1016/j.jacc.2010.02.060. View

Florescu M, Miles C, Florescu D . What do we know about adenovirus in renal transplantation?. Nephrol Dial Transplant. 2013; 28(8):2003-10. DOI: 10.1093/ndt/gft036. View

Howard D, Phillips II G, Reece D, Munn R, Henslee-Downey J, Pittard M . Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 1999; 29(6):1494-501. DOI: 10.1086/313514. View

Leen A, Bollard C, Mendizabal A, Shpall E, Szabolcs P, Antin J . Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood. 2013; 121(26):5113-23. PMC: 3695359. DOI: 10.1182/blood-2013-02-486324. View

Florescu D, Kwon J, Dumitru I . Adenovirus infections in heart transplantation. Cardiol Rev. 2013; 21(4):203-6. DOI: 10.1097/CRD.0b013e31828da5b7. View

10.

Kampmann B, Cubitt D, Walls T, Naik P, Depala M, Samarasinghe S . Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol. 2005; 130(4):595-603. DOI: 10.1111/j.1365-2141.2005.05649.x. View

11.

Liu M, Mallory G, Schecter M, Worley S, Arrigain S, Robertson J . Long-term impact of respiratory viral infection after pediatric lung transplantation. Pediatr Transplant. 2010; 14(3):431-6. PMC: 2893330. DOI: 10.1111/j.1399-3046.2010.01296.x. View

12.

de Mezerville M, Tellier R, Richardson S, Hebert D, Doyle J, Allen U . Adenoviral infections in pediatric transplant recipients: a hospital-based study. Pediatr Infect Dis J. 2006; 25(9):815-8. DOI: 10.1097/01.inf.0000233542.48267.fd. View

13.

Hoffman J . Adenoviral disease in pediatric solid organ transplant recipients. Pediatr Transplant. 2006; 10(1):17-25. DOI: 10.1111/j.1399-3046.2006.00427.x. View

14.

Painter W, Robertson A, Trost L, Godkin S, Lampert B, Painter G . First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses. Antimicrob Agents Chemother. 2012; 56(5):2726-34. PMC: 3346600. DOI: 10.1128/AAC.05983-11. View

15.

Berho M, TORROELLA M, Viciana A, Weppler D, Thompson J, Nery J . Adenovirus enterocolitis in human small bowel transplants. Pediatr Transplant. 1999; 2(4):277-82. View

16.

Shields A, Hackman R, Fife K, Corey L, Meyers J . Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med. 1985; 312(9):529-33. DOI: 10.1056/NEJM198502283120901. View

17.

McLaughlin G, Delis S, Kashimawo L, Cantwell G, Mittal N, Cirocco R . Adenovirus infection in pediatric liver and intestinal transplant recipients: utility of DNA detection by PCR. Am J Transplant. 2003; 3(2):224-8. DOI: 10.1034/j.1600-6143.2003.00007.x. View

18.

Lion T, Baumgartinger R, Watzinger F, Matthes-Martin S, Suda M, Preuner S . Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood. 2003; 102(3):1114-20. DOI: 10.1182/blood-2002-07-2152. View

19.

Baldwin A, Kingman H, Darville M, Foot A, Grier D, Cornish J . Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 2001; 26(12):1333-8. DOI: 10.1038/sj.bmt.1702716. View

20.

Shirali G, Ni J, Chinnock R, Johnston J, Rosenthal G, Bowles N . Association of viral genome with graft loss in children after cardiac transplantation. N Engl J Med. 2001; 344(20):1498-503. DOI: 10.1056/NEJM200105173442002. View