Low Expression of Activating Transcription Factor 3 in Human Hepatocellular Carcinoma and Its Clinicopathological Significance

Overview

Journal Pathol Res Pract

Specialty Pathology

Date 2014 Jun 8

PMID 24906227

Citations 9

Authors

Li Xiaoyan

Zang Shengbing

Zhang Yu

Zheng Lin

Lin Chengjie

Liu Jingfeng

Huang Aimin

Affiliations

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Abstract

Background And Aim: To explore the expression and role of activating transcription factor 3 in human hepatocellular carcinoma.

Methods: Immunohistochemistry, Western blot assay and Real-time PCR were used to evaluate activating transcription factor 3 protein and gene level in HCC clinical samples.

Results: Activating transcription factor 3 expression is lowest in HCC, and the protein level is lower in patients with capsule invasion, while there is no association with other main clinical pathological features.

Conclusions: Low expression of ATF3 may function as a tumor suppressor during human hepatocellular oncogenesis and targeting ATF3 pathway might be beneficial for anti-HCC therapy.

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Role of ATF3 as a prognostic biomarker and correlation of ATF3 expression with macrophage infiltration in hepatocellular carcinoma.

Li L, Song S, Fang X, Cao D BMC Med Genomics. 2021; 14(1):8.

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Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells.

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