TIMP-3 -1296 T>C and TIMP-4 -55 T>C Gene Polymorphisms Play a Role in the Susceptibility of Hepatocellular Carcinoma Among Women

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2014 Jun 7

PMID 24903383

Citations 12

Authors

Hsiu-Ting Tsai

Ming-Ju Hsieh

Hui-Ling Chiou

Hsiang-Lin Lee

Min-Chieh Hsin

Yi-Sheng Liou

Chen-Chieh Yang

Shun-Fa Yang

Wu-Hsien Kuo

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate genetic impact of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC). A total of 759 subjects, including 530 healthy controls and 229 patients with hepatocellular carcinoma, were recruited in this study. Allelic discrimination of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) polymorphisms was assessed with the ABI StepOne™ Real-Time PCR System. Among women group, individuals with TC or CC alleles of TIMP-3 -1296 T>C gene polymorphism protected against HCC (AOR = 0.35, 95% confidence interval (CI) = 0.12-0.97; p = 0.04) compared to individuals with TT alleles, after adjusting for other confounders. Also, women with TC alleles and with TC or CC alleles of TIMP-4 -55 T>C polymorphisms had a 2.52-fold risk (95%CI = 1.23-5.13; p = 0.01) and 2.47-fold risk (95%CI = 1.26-4.87; p = 0.008) of developing HCC compared to individuals with TT alleles, after adjusting for other confounders. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions and clinical statuses of HCC as well as serum expression of liver-related clinicopathological markers. In conclusion, gene polymorphisms of TIMP-3 -1296 T>C (rs9619311) and TIMP-4 -55 T>C (rs3755724) play a role in the susceptibility of HCC among Taiwan women.

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References

Tran P, Vigneron J, Pericat D, Dubois S, Cazals D, Hervy M . Gene therapy for hepatocellular carcinoma using non-viral vectors composed of bis guanidinium-tren-cholesterol and plasmids encoding the tissue inhibitors of metalloproteinases TIMP-2 and TIMP-3. Cancer Gene Ther. 2003; 10(6):435-44. DOI: 10.1038/sj.cgt.7700592. View

Ban J, Yoon K, Kim S, Kang S, Chung J . Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population. Pediatr Cardiol. 2008; 30(3):331-5. DOI: 10.1007/s00246-008-9341-x. View

Wieczorek E, Reszka E, Jablonowski Z, Jablonska E, Krol M, Grzegorczyk A . Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility. BJU Int. 2013; 112(8):1207-14. DOI: 10.1111/bju.12230. View

He Y, Cui Y, Wang W, Gu J, Guo S, Ma K . Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia. 2011; 13(9):841-53. PMC: 3182276. DOI: 10.1593/neo.11698. View

Peterson N, Beeghly-Fadiel A, Gao Y, Long J, Cai Q, Shu X . Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survival. Int J Cancer. 2009; 125(4):844-50. PMC: 2745995. DOI: 10.1002/ijc.24405. View

Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V . Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology. 2008; 136(2):663-72.e4. DOI: 10.1053/j.gastro.2008.10.079. View

Hassan Z, Daghestani M . Curcumin effect on MMPs and TIMPs genes in a breast cancer cell line. Asian Pac J Cancer Prev. 2012; 13(7):3259-64. DOI: 10.7314/apjcp.2012.13.7.3259. View

Pilka R, Oborna I, Lichnovsky V, Havelka P, Fingerova H, Eriksson P . Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patients. Hum Reprod. 2006; 21(12):3146-56. DOI: 10.1093/humrep/del180. View

Tsai H, Yang S, Chen D, Chan S . CCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinoma. Med Oncol. 2012; 29(4):2771-9. DOI: 10.1007/s12032-012-0189-9. View

10.

Okita K . Management of hepatocellular carcinoma in Japan. J Gastroenterol. 2006; 41(2):100-6. DOI: 10.1007/s00535-005-1763-0. View

11.

Hao K, Luk J, Lee N, Mao M, Zhang C, Ferguson M . Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters. BMC Cancer. 2009; 9:389. PMC: 2785835. DOI: 10.1186/1471-2407-9-389. View

12.

Dammann R, Strunnikova M, Schagdarsurengin U, Rastetter M, Papritz M, Hattenhorst U . CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer. 2005; 41(8):1223-36. DOI: 10.1016/j.ejca.2005.02.020. View

13.

Yiang G, Harn H, Yu Y, Hu S, Hung Y, Hsieh C . Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice. J Biomed Sci. 2009; 16:47. PMC: 2687432. DOI: 10.1186/1423-0127-16-47. View

14.

Yu M, Chang H, Chang S, Liaw Y, Lin S, Liu C . Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B- and C-related risk. Hepatology. 2003; 38(6):1393-400. DOI: 10.1016/j.hep.2003.09.041. View

15.

Liu W, Yeh S, Lu C, Yu S, Chen H, Lin C . MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells. Gastroenterology. 2008; 136(2):683-93. DOI: 10.1053/j.gastro.2008.10.029. View

16.

Shen B, Chu E, Zhao G, Man K, Wu C, Cheng J . PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. Br J Cancer. 2012; 106(9):1486-94. PMC: 3341869. DOI: 10.1038/bjc.2012.130. View

17.

Nakamura M, Ishida E, Shimada K, Kishi M, Nakase H, Sakaki T . Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas. Lab Invest. 2004; 85(2):165-75. DOI: 10.1038/labinvest.3700223. View

18.

Pilka R, Domanski H, Hansson S, Eriksson P, Casslen B . Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26. Mol Hum Reprod. 2004; 10(9):641-50. DOI: 10.1093/molehr/gah092. View

19.

Chen Y, Tseng H, Kuo W, Yang S, Chen D, Tsai H . Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med Genet. 2010; 11:46. PMC: 2851593. DOI: 10.1186/1471-2350-11-46. View

20.

Yuan Y, Wang J, Li J, Wang L, Li M, Yang Z . Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res. 2006; 12(22):6687-95. PMC: 1832152. DOI: 10.1158/1078-0432.CCR-06-0921. View