Link Between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases

Overview

Journal Aging Dis

Specialty Geriatrics

Date 2014 Jun 6

PMID 24900943

Citations 50

Authors

Atsuko Nakanishi

Yoko Wada

Yasuko Kitagishi

Satoru Matsuda

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging.

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