The Role of the Ubiquitin-proteasome Pathway in Cancer Development and Treatment

Overview

Journal Front Biosci (Landmark Ed)

Specialty Biology

Date 2014 Jun 5

PMID 24896323

Citations 30

Authors

Fangbao Ding

Haibo Xiao

Mingsong Wang

Xiao Xie

Fengqing Hu

Affiliations

Soon will be listed here.

Abstract

Ubiquitination is a post-translational modification that plays a role in several cellular processes including cell cycle progression, cell proliferation, DNA replication and apoptosis. Ubiquitin-mediated signaling is frequently altered in cancer cells. Several tumor suppressors and oncogenes interact with enzymes of the ubiquitin-proteasome pathway that function in ubiquitin conjugation and deconjugation. Increasing evidence indicates that the ubiquitin-proteasome system (UPS) plays an important role in cancer development. Several small molecule inhibitors of the UPS have been applied to the treatment of cancer. The current review focuses on the role of the UPS in cancer development and the development of UPS inhibitors for cancer treatment.

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