Effects of Long-term Low-level Radiation Exposure After the Chernobyl Catastrophe on Immunoglobulins in Children Residing in Contaminated Areas: Prospective and Cross-sectional Studies

Overview

Journal Environ Health

Publisher Biomed Central

Specialty Environmental Health

Date 2014 Jun 3

PMID 24886042

Citations 3

Authors

Daria M McMahon

Vitaliy Y Vdovenko

Wilfried Karmaus

Valentina Kondrashova

Erik Svendsen

Oksana M Litvinetz

Yevgenia I Stepanova

Affiliations

Soon will be listed here.

Abstract

Background: After the Chernobyl nuclear incident in 1986, children in the Narodichesky region, located 80 km west of the Chernobyl Power Plant, were exposed to 137Cesium (137Cs). Little is known about the effects of chronic low-level radiation on humoral immune responses in children residing in contaminated areas.

Methods: In four different approaches we investigated the effect of residential 137Cs exposure on immunoglobulins A, G, M, and specific immunoglobulin E in children. In a dynamic cohort (1993-1998) we included 617 children providing 2,407 repeated measurements; 421 and 523 children in two cross-sectional samples (1997-1998 and 2008-2010, respectively); and 25 participants in a small longitudinal cohort (1997-2010). All medical exams, blood collections, and analyses were conducted by the same team. We used mixed linear models to analyze repeated measurements in cohorts and general linear regression models for cross-sectional studies.

Results: Residential soil contamination in 2008 was highly correlated with the individual body burden of 137Cs. Serum IgG and IgM concentrations increased between 1993 and 1998. Children with higher 137Cs soil exposure had lower serum IgG levels, which, however, increased in the small cohort assessed between 1997 and 2010. Children within the fourth quintile of 137Cs soil exposure (266-310 kBq/m2) had higher IgM serum concentrations between 1993 and 1998 but these declined between 1997 and 2010. IgA remained stable with median 137Cs exposures related to higher IgA levels, which was corroborated in the cross-sectional study of 2008-2010. Specific IgE against indoor allergens was detected less often in children with higher 137Cs exposure.

Conclusions: Our findings show radiation-related alterations of immunoglobulins which by themselves do not constitute adverse health effects. Further investigations are necessary to understand how these changes affect health status.

Citing Articles

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Dietary supplementation with radionuclide free food improves children's health following community exposure to (137)Cesium: a prospective study.

McMahon D, Vdovenko V, Stepanova Y, Karmaus W, Zhang H, Irving E Environ Health. 2015; 14:94.

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Quantifying annual internal effective Cesium dose utilizing direct body-burden measurement and ecological dose modeling.

Jelin B, Sun W, Kravets A, Naboka M, Stepanova E, Vdovenko V J Expo Sci Environ Epidemiol. 2015; 26(6):546-553.

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