Synaptosomal-associated Protein 25 (Snap-25) Gene Polymorphism Frequency in Fibromyalgia Syndrome and Relationship with Clinical Symptoms

Overview

Journal BMC Musculoskelet Disord

Publisher Biomed Central

Specialties Orthopedics
Physiology

Date 2014 Jun 3

PMID 24885975

Citations 7

Authors

Ayse Balkarli

Cem Sengul

Emre Tepeli

Huseyin Balkarli

Veli Cobankara

Affiliations

Soon will be listed here.

Abstract

Background: SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane transition and fusion. This is important because neurologic, cognitive, and psychologic disorders in fibromyalgia syndrome (FMS) can be related to this function. This relationship may be enlightening for etiopathogenesis of FMS and treatment approaches. We aimed to study a SNAP-25 gene polymorphism, which is related to many psychiatric diseases, and FMS association in this prospective study.

Methods: We included 71 patients who were diagnosed according to new criteria and 57 matched healthy women in this study. Both groups were evaluated regarding age, height, weight, BMI, education level, marital and occupational status. A new diagnosis of FMS was made from criteria scoring, SF-36, Beck depression scale, and VAS that were applied to the patient group. SNAP-25 gene polymorphism and disease activity score correlations were compared.

Results: Mean age was 38±5,196 and 38.12±4.939 in patient and control groups, respectively (p=0.542). No significant difference was found between groups regarding age, height, weight, BMI, education level, marital or occupational status (p > 0.05). Ddel T/C genotype was significantly higher in the patient group (p = 0.009). MnlI gene polymorphism did not show a correlation with any score whereas a significant correlation was found between Ddel T/C genotype and Beck depression scale and VAS score (p < 0.05).

Conclusion: FMS etiopathogenesis is not clearly known. Numerous neurologic, cognitive and psychological disorders were found during studies looking at cause. Our study showed increased SNAP-25 Ddel T/C genotype in FMS patients compared to the control group, which is related to behavioral symptoms, personality and psychological disorders in FMS patients.

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References

Malt E, Olafsson S, Aakvaag A, Lund A, Ursin H . Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord. 2003; 75(1):77-82. DOI: 10.1016/s0165-0327(02)00025-3. View

Arnold L, Hudson J, Keck P, Auchenbach M, Javaras K, Hess E . Comorbidity of fibromyalgia and psychiatric disorders. J Clin Psychiatry. 2006; 67(8):1219-25. DOI: 10.4088/jcp.v67n0807. View

Anisman H, Merali Z . Cytokines, stress and depressive illness: brain-immune interactions. Ann Med. 2003; 35(1):2-11. DOI: 10.1080/07853890310004075. View

Chakrabarty S, Zoorob R . Fibromyalgia. Am Fam Physician. 2007; 76(2):247-54. View

Semiz U, Basoglu C, Oner O, Munir K, Ates A, Algul A . Effects of diagnostic comorbidity and dimensional symptoms of attention-deficit-hyperactivity disorder in men with antisocial personality disorder. Aust N Z J Psychiatry. 2008; 42(5):405-13. PMC: 3166642. DOI: 10.1080/00048670801961099. View

van Houdenhove B, Neerinckx E, Onghena P, Lysens R, Vertommen H . Premorbid "overactive" lifestyle in chronic fatigue syndrome and fibromyalgia. An etiological factor or proof of good citizenship?. J Psychosom Res. 2001; 51(4):571-6. DOI: 10.1016/s0022-3999(01)00247-1. View

Holman A, Myers R . A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum. 2005; 52(8):2495-505. DOI: 10.1002/art.21191. View

Hu C, Ahmed M, Melia T, Sollner T, Mayer T, Rothman J . Fusion of cells by flipped SNAREs. Science. 2003; 300(5626):1745-9. DOI: 10.1126/science.1084909. View

Buskila D, Dan B, Cohen H, Hagit C, Neumann L, Lily N . An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry. 2004; 9(8):730-1. DOI: 10.1038/sj.mp.4001506. View

10.

Faraone S, Perlis R, Doyle A, Smoller J, Goralnick J, Holmgren M . Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005; 57(11):1313-23. DOI: 10.1016/j.biopsych.2004.11.024. View

11.

Fietta P, Fietta P, Manganelli P . Fibromyalgia and psychiatric disorders. Acta Biomed. 2007; 78(2):88-95. View

12.

Fries E, Hesse J, Hellhammer J, Hellhammer D . A new view on hypocortisolism. Psychoneuroendocrinology. 2005; 30(10):1010-6. DOI: 10.1016/j.psyneuen.2005.04.006. View

13.

Gursoy S, Erdal E, Herken H, Madenci E, Alasehirli B . Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome. Rheumatol Int. 2001; 21(2):58-61. DOI: 10.1007/s002960100130. View

14.

Gosso M, de Geus E, van Belzen M, Polderman T, Heutink P, Boomsma D . The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. Mol Psychiatry. 2006; 11(9):878-86. DOI: 10.1038/sj.mp.4001868. View

15.

Ablin J, Cohen H, Buskila D . Mechanisms of Disease: genetics of fibromyalgia. Nat Clin Pract Rheumatol. 2006; 2(12):671-8. DOI: 10.1038/ncprheum0349. View

16.

Corradini I, Verderio C, Sala M, Wilson M, Matteoli M . SNAP-25 in neuropsychiatric disorders. Ann N Y Acad Sci. 2009; 1152:93-9. PMC: 2706123. DOI: 10.1111/j.1749-6632.2008.03995.x. View

17.

Bradley L . Pathophysiologic mechanisms of fibromyalgia and its related disorders. J Clin Psychiatry. 2008; 69 Suppl 2:6-13. View

18.

van Houdenhove B, Neerinckx E, Lysens R, Vertommen H, Van Houdenhove L, Onghena P . Victimization in chronic fatigue syndrome and fibromyalgia in tertiary care: a controlled study on prevalence and characteristics. Psychosomatics. 2001; 42(1):21-8. DOI: 10.1176/appi.psy.42.1.21. View

19.

Golimbet V, Alfimova M, Gritsenko I, Lezheiko T, Lavrushina O, Abramova L . Association between a synaptosomal protein (SNAP-25) gene polymorphism and verbal memory and attention in patients with endogenous psychoses and mentally healthy subjects. Neurosci Behav Physiol. 2010; 40(4):461-5. DOI: 10.1007/s11055-010-9280-x. View

20.

Thieme K, Turk D, Flor H . Comorbid depression and anxiety in fibromyalgia syndrome: relationship to somatic and psychosocial variables. Psychosom Med. 2004; 66(6):837-44. DOI: 10.1097/01.psy.0000146329.63158.40. View