Endothelial Function is Impaired in Conduit Arteries of Pannexin1 Knockout Mice

Overview

Journal Biol Direct

Publisher Biomed Central

Specialty Biology

Date 2014 Jun 3

PMID 24885326

Citations 8

Authors

Dina Gaynullina

Olga S Tarasova

Oxana O Kiryukhina

Valery I Shestopalov

Yuri Panchin

Affiliations

Soon will be listed here.

Abstract

Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative to smooth muscle of saphenous artery. The ability of endothelium-intact arteries for dilation was significantly impaired whereas contractile responses were considerably increased in mice with genetic ablation of Pannexin1. No such increased contractile responses were detected in the endothelium-denuded arteries. Combined, our findings suggest a new function of Pannexin1 as an important player in normal endothelium-dependent regulation of arterial tone, where it facilitates vessel dilation and attenuates constriction.

Citing Articles

Pannexin 1 Transgenic Mice: Human Diseases and Sleep-Wake Function Revision.

Battulin N, Kovalzon V, Korablev A, Serova I, Kiryukhina O, Pechkova M Int J Mol Sci. 2021; 22(10).

PMID: 34067798 PMC: 8155943. DOI: 10.3390/ijms22105269.

Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases.

Brocardo L, Acosta L, Piantanida A, Rela L Front Cell Neurosci. 2019; 13:491.

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Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.

Novielli-Kuntz N, Jelen M, Barr K, DeLalio L, Feng Q, Isakson B Biosci Rep. 2019; 39(2).

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Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis.

Boucher J, Simonneau C, Denet G, Clarhaut J, Balandre A, Mesnil M Int J Mol Sci. 2018; 19(6).

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Connexins and Pannexins in Vascular Function and Disease.

Molica F, Figueroa X, Kwak B, Isakson B, Gibbins J Int J Mol Sci. 2018; 19(6).

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