From Gene Action to Reactive Genomes

Overview

Journal J Physiol

Specialty Physiology

Date 2014 Jun 3

PMID 24882822

Citations 15

Authors

Evelyn Fox Keller

Affiliations

Soon will be listed here.

Abstract

Poised at a critical turning point in the history of genetics, recent work (e.g. in genomics, epigenetics, genomic plasticity) obliges us to critically reexamine many of our most basic concepts. For example, I argue that genomic research supports a radical transformation in our understanding of the genome--a shift from an earlier conception of that entity as an effectively static collection of active genes to that of a dynamic and reactive system dedicated to the context specific regulation of protein-coding sequences.

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