Chronic Diseases and Conditions Related to Alcohol Use

Overview

Journal Alcohol Res

Specialty Psychiatry

Date 2014 Jun 3

PMID 24881324

Citations 203

Authors

Kevin D Shield

Charles Parry

Jurgen Rehm

Affiliations

Soon will be listed here.

Abstract

Alcohol consumption is a risk factor for many chronic diseases and conditions. The average volume of alcohol consumed, consumption patterns, and quality of the alcoholic beverages consumed likely have a causal impact on the mortality and morbidity related to chronic diseases and conditions. Twenty-five chronic disease and condition codes in the International Classification of Disease (ICD)-10 are entirely attributable to alcohol, and alcohol plays a component-risk role in certain cancers, other tumors, neuropsychiatric conditions, and numerous cardiovascular and digestive diseases. Furthermore, alcohol has both beneficial and detrimental impacts on diabetes, ischemic stroke, and ischemic heart disease, depending on the overall volume of alcohol consumed, and, in the case of ischemic diseases, consumption patterns. However, limitations exist to the methods used to calculate the relative risks and alcohol-attributable fractions. Furthermore, new studies and confounders may lead to additional diseases being causally linked to alcohol consumption, or may disprove the relationship between alcohol consumption and certain diseases that currently are considered to be causally linked. These limitations do not affect the conclusion that alcohol consumption significantly contributes to the burden of chronic diseases and conditions globally, and that this burden should be a target for intervention.

Citing Articles

Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption.

Hemati H, Blanton M, True H, Koura J, Khadka R, Grant K bioRxiv. 2025; .

PMID: 39975066 PMC: 11839131. DOI: 10.1101/2025.02.05.636708.

Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke.

Kim J, Kim B, Kang J, Kim D, Han M, Kim S J Stroke. 2025; 27(1):102-112.

PMID: 39916459 PMC: 11834334. DOI: 10.5853/jos.2024.00661.

Alcohol consumption, polygenic risk score, and the risk of colorectal neoplasia.

Fu R, Chen X, Seum T, Hoffmeister M, Brenner H JNCI Cancer Spectr. 2025; 9(2).

PMID: 39898811 PMC: 11901593. DOI: 10.1093/jncics/pkaf017.

Screening for Alcohol Use Disorder Among Hospitalised Patients: Learning from a Retrospective Cohort Study in Secondary Care.

Subhani M, Nath D, Talat U, Imtiaz A, Khanna A, Ali A J Clin Med. 2025; 13(24.

PMID: 39768540 PMC: 11678479. DOI: 10.3390/jcm13247617.

Adherence to Pulmonary Tuberculosis Medication and Associated Factors Among Adults: A Cross-Sectional Study in the Metinaro and Becora Sub-Districts, Dili, Timor-Leste.

Fernandes A, Laohaprapanon S, Nam T, Sequeira E, Le C Int J Environ Res Public Health. 2025; 21(12.

PMID: 39767501 PMC: 11675860. DOI: 10.3390/ijerph21121662.

References

Sierksma A, Patel H, Ouchi N, Kihara S, Funahashi T, Heine R . Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care. 2003; 27(1):184-9. DOI: 10.2337/diacare.27.1.184. View

Rockhill B, Newman B, WEINBERG C . Use and misuse of population attributable fractions. Am J Public Health. 1998; 88(1):15-9. PMC: 1508384. DOI: 10.2105/ajph.88.1.15. View

Kwo P, Ramchandani V, OConnor S, Amann D, CARR L, Sandrasegaran K . Gender differences in alcohol metabolism: relationship to liver volume and effect of adjusting for body mass. Gastroenterology. 1998; 115(6):1552-7. DOI: 10.1016/s0016-5085(98)70035-6. View

Irving H, Samokhvalov A, Rehm J . Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP. 2009; 10(4):387-92. PMC: 3299482. View

Grant B, Pickering R . Familial aggregation of DSM-IV alcohol use disorders: examination of the primary-secondary distinction in a general population sample. J Nerv Ment Dis. 1997; 185(5):335-43. DOI: 10.1097/00005053-199705000-00008. View

Braithwaite R, Bryant K . Influence of alcohol consumption on adherence to and toxicity of antiretroviral therapy and survival. Alcohol Res Health. 2013; 33(3):280-7. PMC: 3860503. View

Braithwaite R, Conigliaro J, McGinnis K, Maisto S, Bryant K, Justice A . Adjusting alcohol quantity for mean consumption and intoxication threshold improves prediction of nonadherence in HIV patients and HIV-negative controls. Alcohol Clin Exp Res. 2008; 32(9):1645-51. PMC: 3111093. DOI: 10.1111/j.1530-0277.2008.00732.x. View

Lachenmeier D, Rehm J . Unrecorded alcohol: a threat to public health?. Addiction. 2009; 104(6):875-7. DOI: 10.1111/j.1360-0443.2009.02587.x. View

Zakhari S . Alcohol and the cardiovascular system: molecular mechanisms for beneficial and harmful action. Alcohol Health Res World. 1997; 21(1):21-9. PMC: 6826791. View

10.

Bellocco R, Pasquali E, Rota M, Bagnardi V, Tramacere I, Scotti L . Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis. Ann Oncol. 2012; 23(9):2235-2244. DOI: 10.1093/annonc/mds022. View

11.

Taylor B, Irving H, Baliunas D, Roerecke M, Patra J, Mohapatra S . Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction. 2009; 104(12):1981-90. DOI: 10.1111/j.1360-0443.2009.02694.x. View

12.

Verdoux H, Lengronne J, Liraud F, Gonzales B, Assens F, Abalan F . Medication adherence in psychosis: predictors and impact on outcome. A 2-year follow-up of first-admitted subjects. Acta Psychiatr Scand. 2000; 102(3):203-10. DOI: 10.1034/j.1600-0447.2000.102003203.x. View

13.

Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C . Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008; (2):CD007176. DOI: 10.1002/14651858.CD007176. View

14.

Baliunas D, Taylor B, Irving H, Roerecke M, Patra J, Mohapatra S . Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis. Diabetes Care. 2009; 32(11):2123-32. PMC: 2768203. DOI: 10.2337/dc09-0227. View

15.

Facchini F, Chen Y, Reaven G . Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care. 1994; 17(2):115-9. DOI: 10.2337/diacare.17.2.115. View

16.

Taylor J, Dolhert N, Friedman L, Mumenthaler M, Yesavage J . Alcohol elimination and simulator performance of male and female aviators: a preliminary report. Aviat Space Environ Med. 1996; 67(5):407-13. View

17.

Rimm E, Williams P, Fosher K, Criqui M, Stampfer M . Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999; 319(7224):1523-8. PMC: 28294. DOI: 10.1136/bmj.319.7224.1523. View

18.

Zaghloul S, Goodfield M . Objective assessment of compliance with psoriasis treatment. Arch Dermatol. 2004; 140(4):408-14. DOI: 10.1001/archderm.140.4.408. View

19.

Zatonski W, Sulkowska U, Manczuk M, Rehm J, Boffetta P, Lowenfels A . Liver cirrhosis mortality in Europe, with special attention to Central and Eastern Europe. Eur Addict Res. 2010; 16(4):193-201. DOI: 10.1159/000317248. View

20.

Eagon P . Alcoholic liver injury: influence of gender and hormones. World J Gastroenterol. 2010; 16(11):1377-84. PMC: 2842530. DOI: 10.3748/wjg.v16.i11.1377. View