Identification of Erythroferrone As an Erythroid Regulator of Iron Metabolism

Overview

Journal Nat Genet

Specialty Genetics

Date 2014 Jun 2

PMID 24880340

Citations 469

Authors

Leon Kautz

Grace Jung

Erika V Valore

Stefano Rivella

Elizabeta Nemeth

Tomas Ganz

Affiliations

Soon will be listed here.

Abstract

Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.

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