Is Renal Function Associated with Early Age-related Macular Degeneration?

Overview

Journal Optom Vis Sci

Date 2014 Jun 1

PMID 24879085

Citations 6

Authors

Elaine W Chong

Robyn H Guymer

Ronald Klein

Barbara E Klein

Mary Frances Cotch

Jie Jin Wang

Michael G Shlipak

Tien Y Wong

Affiliations

Soon will be listed here.

Abstract

Purpose: Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD.

Methods: A population-based, cross-sectional analysis of persons aged 45 to 84 years was conducted with renal function measured using serum creatinine and cystatin C levels and the estimated glomerular filtration rate (eGFR) calculated. Age-related macular degeneration status was ascertained from retinal photographs.

Results: Of 5874 participants, 221 had early AMD. High serum cystatin C and low eGFR (≤60 ml/min/1.73 m) were not associated with early AMD in our multivariate analyses. Among normotensive persons, however, highest versus other deciles of cystatin C were associated with an increased prevalence of early AMD (odds ratio, 1.80; 95% confidence interval, 1.00 to 3.23).

Conclusions: Results could not confirm an association between kidney function and early AMD. The borderline association between cystatin C and early AMD in normotensive persons require further verification.

Citing Articles

Association between chronic kidney disease and age-related macular degeneration: a Mendelian randomization study.

Hou Y, Liu Q, Xiao Z, Li Y, Tian X, Wang Z Front Aging Neurosci. 2024; 16:1399666.

PMID: 38872627 PMC: 11169943. DOI: 10.3389/fnagi.2024.1399666.

Association of eGFR with stages of diabetic retinopathy and age-related macular degeneration in Indian population.

Neelamegam V, Surya R, Venkatakrishnan P, Sharma T, Raman R Indian J Ophthalmol. 2024; 72(7):968-975.

PMID: 38454846 PMC: 11329835. DOI: 10.4103/IJO.IJO_2558_23.

Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up.

Jung W, Park J, Jang H, Jeon J, Han K, Kim B Sci Rep. 2023; 13(1):183.

PMID: 36604459 PMC: 9814881. DOI: 10.1038/s41598-022-26964-8.

Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes.

Dave A, Hess K, Chen K, Wiley H, Keenan T, Agron E Transl Vis Sci Technol. 2022; 11(12):11.

PMID: 36525252 PMC: 9766786. DOI: 10.1167/tvst.11.12.11.

Association between macular degeneration and mild to moderate chronic kidney disease: A nationwide population-based study.

Chen C, Dai C, Lee C, Shyu Y, Huang T, Yeung L Medicine (Baltimore). 2017; 96(11):e6405.

PMID: 28296786 PMC: 5369941. DOI: 10.1097/MD.0000000000006405.

References

Haines J, Hauser M, Schmidt S, Scott W, Olson L, Gallins P . Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005; 308(5720):419-21. DOI: 10.1126/science.1110359. View

Tan J, Mitchell P, Smith W, Wang J . Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology. 2007; 114(6):1143-50. DOI: 10.1016/j.ophtha.2006.09.033. View

Short C, Raines M, Gokal R, Lawler W . Fundus changes in mesangiocapillary glomerulonephritis type II: clinical and fluorescein angiographic findings. Br J Ophthalmol. 1989; 73(11):900-6. PMC: 1041923. DOI: 10.1136/bjo.73.11.900. View

. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997; 20(7):1183-97. DOI: 10.2337/diacare.20.7.1183. View

MACDONALD M, McKechnie N . Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report. Br J Ophthalmol. 1989; 73(4):297-302. PMC: 1041718. DOI: 10.1136/bjo.73.4.297. View

Jonasson F, Arnarsson A, Eiriksdottir G, Harris T, Launer L, Meuer S . Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. Ophthalmology. 2010; 118(5):825-30. PMC: 3087833. DOI: 10.1016/j.ophtha.2010.08.044. View

Grubb A, Nyman U, Bjork J, Lindstrom V, Rippe B, Sterner G . Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem. 2005; 51(8):1420-31. DOI: 10.1373/clinchem.2005.051557. View

Poggio E, Wang X, Greene T, Van Lente F, Hall P . Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease. J Am Soc Nephrol. 2004; 16(2):459-66. DOI: 10.1681/ASN.2004060447. View

Attebo K, Mitchell P, Smith W . Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996; 103(3):357-64. DOI: 10.1016/s0161-6420(96)30684-2. View

10.

Levey A, Coresh J . Chronic kidney disease. Lancet. 2011; 379(9811):165-80. DOI: 10.1016/S0140-6736(11)60178-5. View

11.

Shlipak M, Katz R, Sarnak M, Fried L, Newman A, Stehman-Breen C . Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med. 2006; 145(4):237-46. DOI: 10.7326/0003-4819-145-4-200608150-00003. View

12.

Edwards A, Ritter 3rd R, Abel K, Manning A, Panhuysen C, Farrer L . Complement factor H polymorphism and age-related macular degeneration. Science. 2005; 308(5720):421-4. DOI: 10.1126/science.1110189. View

13.

Klein R, Klein B, Linton K . Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992; 99(6):933-43. DOI: 10.1016/s0161-6420(92)31871-8. View

14.

Thompson C, Klein B, Klein R, Xu Z, Capriotti J, Joshi T . Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes. Hum Mol Genet. 2007; 16(17):2135-48. DOI: 10.1093/hmg/ddm164. View

15.

Liew G, Mitchell P, Wong T, Iyengar S, Wang J . CKD increases the risk of age-related macular degeneration. J Am Soc Nephrol. 2008; 19(4):806-11. PMC: 2390960. DOI: 10.1681/ASN.2007080844. View

16.

Sarnak M, Katz R, Stehman-Breen C, Fried L, Jenny N, Psaty B . Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005; 142(7):497-505. DOI: 10.7326/0003-4819-142-7-200504050-00008. View

17.

Hageman G, Anderson D, Johnson L, Hancox L, Taiber A, Hardisty L . A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005; 102(20):7227-32. PMC: 1088171. DOI: 10.1073/pnas.0501536102. View

18.

Barrett A . The cystatins: a diverse superfamily of cysteine peptidase inhibitors. Biomed Biochim Acta. 1986; 45(11-12):1363-74. View

19.

Klein R, Klein B, Knudtson M, Wong T, Cotch M, Liu K . Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology. 2006; 113(3):373-80. DOI: 10.1016/j.ophtha.2005.12.013. View

20.

Choi J, Moon J, Shin H . Chronic kidney disease, early age-related macular degeneration, and peripheral retinal drusen. Ophthalmic Epidemiol. 2011; 18(6):259-63. DOI: 10.3109/09286586.2011.602509. View