Impact of Neoadjuvant Chemotherapy on Immediate Breast Reconstruction: a Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jun 1

PMID 24878776

Citations 23

Authors

Junlong Song

Xiang Zhang

Qiang Liu

Jianheng Peng

Xinjie Liang

Yuanyuan Shen

Hongtao Liu

Hongyuan Li

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to perform a meta-analysis of published studies for evaluating the impact of neoadjuvant chemotherapy (NAC) on immediate breast reconstruction.

Methods: We searched medical databases to identify appropriate studies that assessed the impact of NAC on immediate breast reconstruction from the inception of this technique through April 2013. We then performed a meta-analysis of these studies.

Results: Our searches identified 11 studies among 1,840 citations. In the meta-analysis, NAC did not increase the overall rate of complications after immediate breast reconstruction (odds ratio [OR] = 0.59; 95% confidence interval[CI] = 0.38-0.91). The complication rate was also unaffected by NAC when we considered infections (OR = 0.82; 95% CI = 0.46-1.45), hematomas (OR = 1.35; 95% CI = 0.57-3.21), and seromas (OR = 0.77; 95% CI = 0.23-2.55). Additionally, expander or implant loss did not significantly increase in patients after NAC (OR = 1.59; 95% CI = 0.91-2.79). Only 2 studies (202 procedures) had reported total autologous flap loss, and they were included in our analysis; both studies found no association between NAC and total flap loss.

Conclusion: Our analysis suggests that NAC does not increase the complication rate after immediate breast reconstruction. For appropriately selected patients, immediate breast reconstruction following NAC is a safe procedure. The best way to study this issue in the future is to conduct a multicenter prospective study with a longer follow-up period and more clearly defined parameters.

Citing Articles

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Impact of Neoadjuvant Chemotherapy and Preoperative Irradiation on Early Complications in Direct-to-Implant Breast Reconstruction.

Hwang J, Kim S, Park J, Woo K Arch Plast Surg. 2024; 51(5):466-473.

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Sasada S, Kumamaru H, Hayashi N, Kinukawa N, Toi M, Jinno H Breast Cancer. 2024; 31(5):909-916.

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Zhao J, Chen Z, Wang M, Hai L, Xiao C Aesthetic Plast Surg. 2023; 47(6):2304-2321.

PMID: 37700196 DOI: 10.1007/s00266-023-03644-0.

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